This study focuses on the migration and functional activity of immunocompetent cells in the intestinal contents in people with various pathologies of the gastrointestinal tract and in practically healthy people. Actively phagocytic neutrophilic granulocytes and monocytes, as well as lymphocytes without signs of degeneration and plasma cells, were recorded in the intestinal contents. Differences in the migration activity of cells depended on the pathology of the gastrointestinal tract. The levels of immunocompetent cells in the contents of the intestine in practically healthy people were determined. In gastrointestinal diseases, abnormal concentrations of pro-inflammatory cytokines are detected at a high frequency, the highest content of these cytokines have been recorded in malignant intestinal neoplasms.

100 villous chorions at 9-12 weeks of pregnancy were studied in order to identify the relationship between the indicators of progesterone synthetic activity of the fetoplacental complex being formed and the nature of clinical and echographic manifestations of the threatened miscarriage in groups of women with different course of cytomegalovirus infection (CMV) infection. It was identified a significant dependence of the frequency of the threatened miscarriage and its clinical and echographic manifestations on the exacerbation of CMV infection in the first trimester of pregnancy, which was combined with low values of progesterone and 3β-hydroxy-5-pregnen-20-one-dehydrogenase in the villous chorion compared to the group with a latent course of infection.

A study of serum vitamin D levels in patients with various forms of tuberculosis who were on hospital treatment in 2017-2018 was conducted. Vitamin D deficiency was found to occur in 95, 5% of those examined. Serious deficiency with the level of 25(OH) D below 10 ng/ml was found in 48, 9% of patients.

The article analyzes results of the combined treatment of patients, aged 16 to 64, after the simultaneous surgery on the abdominal organs for visceroptosis, during the early postoperative period. Studies of the immune status were conducted against the background of immunocorrective therapy. Thymogen and polyoxidonium were used as immunocorrectors. Use of the immunocorrective therapy allowed achieving a significant improvement in the dynamics of immune indicators in patients compared to a control group. The polyoxidonium effect on immunological parameters was strongly pronounced and significantly exceeded the effect of thymogen.

This paper presents the results of a cytological study of patients with pathology of the cervix uteri (CU) based on traditional cytology (TC) and on liquid-based cytology (LBC). It was found that the combined use of liquid-based cytology and conventional cytology can improve the effectiveness of CU pathology diagnostics. It is recommended to complete the cytological study with testing for human papillomavirus (HPV). The use of these screening methods (cytological and HPV tests) contribute to improving the early diagnosis, monitoring, and prognosis of CU cancer.

The aim of the study was to identify the risk predictors of developing acute kidney injury (AKI) and to create an AKI prognosis chart for patients with coronary artery disease (CAD) undergoing off-pump coronary artery bypass grafting.
The signs of AKI after the surgery were observed in 42.4% of patients. Out of the numerous factors, 17 most significant signs of the risk of developing AKI were selected using the Wald test. Using the identified signs, we built models (1) and (2) for predicting the probability of developing AKI with the sensitivity of 81% and specificity of 91%. We also revealed increased probability of developing AKI in patients with concomitant metabolic syndrome.

The article presents the results of a study of the frequency and clinical profile of apathy in patients with Parkinson's disease and Huntington's disease. A similar frequency of apathy was found in these two neurodegenerative diseases, but with different clinical correlations, due to the involvement of different brain regions in the pathological process. Thus, in patients with Parkinson's disease, a positive correlation was found between apathy and severe depression, anxiety and drowsiness, while in patients with Huntington's disease – with the duration of the disease and cognitive disorders. Thus apathy as a non-motor symptom of the two neurodegenerative disorders has a similar prevalence, but different clinical profile: in Parkinson's disease, it is mainly associated with emotional and affective disorders («emotional apathy»), while in Huntington's disease – with cognitive disorders («cognitive apathy»).

We conducted research of the plasma enzymatic activities in RA patients with different clinical manifestations. The dependence of XO, XDG, SOD activities on RA activity and presence of extra-articular manifestations was analyzed. We have revealed substantial changes in all the plasma enzymatic activities of RA patients. These changes were multidirectional. XO and SOD activities were increased in all RA patients. XO activity have been reached its highest values at maximum disease activity and presence extra-articular involvements, SOD activity – in moderate and high disease activities as well as in patients with articular form of RA. XDG activity was increased at low disease activity and articular form of RA, while moderate, high disease activities and extra-articular involvements were characterized by decreased activity of this enzyme. Plasma enzymatic profile in RA patients is characterized by an increase of an increase in the intensity of oxidative and antioxidant processes.

A retrospective analysis of medical records of 100 patients aged 59 years and older, who were on treatment at the Geriatric Center of the Republican Hospital №3, was done. The study examined the relationship between STOP/START compliance rates, the state of polypharmacy, compliance with treatment standards and protocols, and the risk of falling in elderly and senile patients.

The aim of the study was to assess the structure of congenital heart defects in children of different ethnic groups living in the Republic of Sakha (Yakutia). Over a 10-year period, the number of newborns with complex CHD has increased significantly in the Pediatric center of the Republican hospital №1-NCM. Children of the indigenous peoples of Yakutia (Yakuts and natives) were more likely to have complex heart defects than children of other ethnic groups.

The article presents the results of studies of the level of psycho-emotional state and steroid hormones in highly qualified martial artists in the pre-competition period. The comparison group consisted of young male students engaged in physical education at least twice a week. It was revealed that indicators of the psychoemotional state did not have significant differences in the examined groups and varied within normal limits. It was shown that the level of hormones also varied within normal limits.The testosterone content did not have statistically significant differences in both groups. The level of cortisol in the group of athletes was statistically significantly lower than that of students. For the full realization of the potential capabilities of athletes in competitions and their achievement of the highest sports result, great attention must be paid to the psychological support system.

In this work, we analyzed the resource provision in the Central Economic Zone (CEZ) according to the indicators included in the official statistical reporting: the availability of medical personnel (doctors, paramedics), round-the-clock hospital beds (all per 10,000 population) and the capacity of outpatient clinics institutions (OCI, in shift visits). An analysis is made of the relationship of a number of indicators characterizing public health with the resource provision of districts / uluses, by correlation coefficients calculated for the period 2007-2016.

This paper presents the results of the development of a medical diagnostic service that is based on a model of medical knowledge and an intelligent decision-maker. The development of decision support systems that accumulate advanced knowledge in the diagnosis and treatment of diseases is an important area of medical informatization. Such systems are especially relevant in the period of major epidemic outbreaks, when a huge number of doctors of various profiles are involved in the process of diagnosis, time for decision-making and prescription of treatment is very short, and the diagnosis itself, due to continuous acquisition of new knowledge, is constantly being improved and refined. The methods of artificial intelligence with ontological knowledge bases are the most ready for this challenge. The work describes a cloud service implemented on the IACPaaS platform for differential diagnosis of coronavirus infections (SARS, MERS and COVID-19) from other infections of the respiratory tract of viral etiology.

The microbiological and molecular genetic characteristics of S. pneumoniae strains, identified during nasopharyngeal carriage, were determined in patients from the age of 6 months up to 85 years old, living in Yakutsk.
The obtained data indicate the prevalence of virulent antibiotic-resistant S. pneumoniae strains among the population of Yakutsk and dictate the need for further epidemiological and microbio-logical studies of this problem.

The article presents the results of the study of the contamination forms of agricultural and wild animals, small mammals, as well as the infection of cohorts of the population with different types of leptospires. The etiological structure of leptospirosis and quantitative and serological indicators of immunological response in animals and humans have been studied. Modern epizootic and epidemiological evaluation of the intensity potential ("softening" of tension) and forecasting of the indicated problem (in the format of reduction, but not elimination of the nosological form) are given.

The aim of the study was analysis of the behavioral factors contributing to the spread of diphyllobothriasis in Yakutia. The results of a survey of accessible respondents from Yakutsk and 32 municipal districts of the republic showed that among the population of the republic, traditions of eating raw and lightly salted home-salted fish are preserved.
We need the widespread introduction of wastewater disinfection technologies, improving the quality of treatment, monitoring fish products, conduct a qualitative helminthological examination of the population, verification of effectiveness of deworming and inform the population about the methods for preventing parasitic infection.

Introduction: Breast, cervical, and ovary cancer are the most common caused-of death cancer in women population in the world, so does in Russia. This study aims to depict breast, cervical, and ovary cancer mortality and years of life lost (YLL) trends in the Republic of Sakha (Yakutia) in the period 2006-2016.
Methods: Data were obtained through the database of the Republic of Sakha (Yakutia) federal state statistics service (Rosstat) which included with ICD-10 code for cause of death.
Results: There were 11.1% deaths caused by breast cancer, 6.9% by cervical cancer, and 4.6% caused by ovary cancer from all death caused by cancer in women population in the research period. YLL from those cancers respectively were 9032, 7796, and 4545 life years. Average years of life lost (AYLL) of those cancers were 13.4; 20.1; and 16.2 life years.
Conclusion: Mortality, YLL, and AYLL due to breast and ovary cancer decreased when those variables increased in cervical cancer. Based on YLL, cervical cancer is now leading to a greater number of deaths among younger generations of women in the Republic of Sakha (Yakutia). Breast cancer remains the dominant cause of cancer death.

The main trends in the tuberculosis (TB) incidence in the Sakha Republic (Yakutia), over the period from 2013 to 2018 were revealed.
The following rates were analyzed (based on reports from facilities subordinate to Ministry of Health of the Sakha Republic (Yakutia), and reports from all agencies irrespective of subordination): TB incidence rates among general population; TB incidence among adults; TB incidence among children and adolescents; TB incidence among urban and rural population; incidence of pulmonary TB; incidence of TB cases positive for M.tuberculosis (MTB); incidence of multidrug-resistant tuberculosis (MDR) in Sakha Republic (Yakutia) in the dynamics. Favorable epidemiologic situation for TB was observed. The obtained findings call for more improvements in conducting anti-TB activities among rural population, and comprehensive measures to decrease the incidence of MDR TB.

The study was conducted in a group of patients with alcohol dependence after detoxification to identify the relationship between indicators of cognitive functioning and clinical features of the formation and course of alcohol dependence.
It was found that alcohol dependence causes a heterogeneous change in the level of cognitive functioning: violation of inhibitory control, decrease in the volume of spatial working memory, attention and cognitive flexibility. Statistically significant correlations were found between clinical data and the degree of cognitive impairment.
Thus, the earlier age of the first sample of alcohol significantly affects the reduction of brake control, which increases the risk of forming alcohol dependence at a young age. The age of alcohol dependence and the associated number of hospitalizations leads to impaired cognitive functioning in the form of reduced spatial working memory and cognitive flexibility. The severity of alcohol dependence primarily determines the degree of cognitive flexibility decline.

A case-control study was conducted in Kolymskoye and Andryushkino of Nizhnekolymsky district of Yakutia to determine the association of IL-6 gene polymorphism with arterial hypertension (AH) and risk factors. The relationship with AH and its risk factors for IL-6 gene polymorphism was obtained, namely, the influence of the G allele of the polymorphic locus C-174G and the C allele of the polymorphic locus C-572G on metabolic factors of atherogenesis. Hypertensive patients - carriers of the G allele of the C-174G polymorphic locus of the IL-6 gene, both in the homozygous and heterozygous versions, showed the highest average systolic blood pressure, a high incidence of abdominal obesity, lipid and carbohydrate metabolism disorders. The study of the polymorphic locus C-572G of the IL-6 gene in patients with hypertension showed the highest incidence of abdominal obesity, lipid and carbohydrate metabolism disorders in carriers of the C allele.

The article presents official medical data on child mortality in 5 regions of the Arctic zone of the Republic Sakha (Yakutia) for 2006-2018. For a more detailed analysis of child mortality, a special database of the state institution "Yakut Republican medical information and analytical center of the Ministry of health of the Republic Sakha (Yakutia)" is used, which includes all cases of death of a child from 0 to 18 years for 2006-2015, indicating age, gender, nationality and cause of death. The analysis of child mortality revealed the tendency of distinct decrease in infant mortality, a decrease in the share of child mortality. In general, a decrease to the minimum values of the average child mortality rates in the Arctic regions of the RS (Ya) is noted.

A study was carried out to determine the dynamics of collagenase levels of the second subfamily (MMR-2, MMR-9) and their inhibitors (TIMP1 and TIMP-2) in blood of patients with local cold injury (LCI). It was found out that in patients with LCI the level of MMR-2 and MMR-9 in serum increases with respect to the control group in the early period of cryodamage, and also the indices of the studied markers increase directly proportional to the volume of the affected tissues. The same dynamics was observed in the study of matrix metalloproteinase inhibitors parameters. On the basis of the obtained data and analysis of the linear regression equation a prognostic model was formed, which allows to suspect with high accuracy the level of tissue affection in the early terms of local cold injury.

In this paper we presented the results of the study of an annual variation of thyroid hormones and autoantibodies in 20 healthy men. There were shown the significant intra-annual rhythms of the total iodothyronines levels with lower values in the autumn-winter period. The annual variation in serum antibodies to thyroid peroxidase showed a significant increase in antibody levels in the autumn-winter period compared to the spring one. The levels of thyroglobulin, a marker of thyroid activity, were statistically significantly higher in the spring compared to the autumn.

The article presents a review of the literature on the problem of metabolic syndrome in children and adolescents. The obesity pandemic, which is now observed all over the world, is an increasingly important social problem, as it leads to an epidemic of cardiovascular diseases, which are the leading causes of death and disability.

The frequency of alleles and haplotypes of blood groups AB0, MN, Rhesus and Kell in the sample of indigenous population of Kyzyl city was studied in comparison with some Siberian populations belonging to other language groups.
It is shown that Tuvinians of Kyzyl city are genetically close to Yakuts and southern Altaians, and the combination of Caucasian and Mongoloid genetic markers reflects their complex ethnic history.

To study the prevalence of gastroesophageal reflux disease (GERD), erosive and ulcerative diseases of gastroduodenal zone and their association in schoolchildren from different regions of Siberia with hereditary predisposition to stomach pathology, schoolchildren from the Republic of Tyva, Buryatia and Evenkia were examined. The prevalence of GERD among schoolchildren in Tyva was higher than in Buryatia and Evenkia. The destructive process of stomach mucosa and duodemum was also higher in Tyva. In children with erosive ulcerative lesions of the gastroduodenal zone, comorbidity of the esophagus was also more frequently determined.
The significant influence of family predisposition to stomach pathology on the prevalence of GERD, erosive- ulcer diseases of gastroduodenal zone, as well as their association in Siberian schoolchildren was established. At the same time, territorial features influence the severity of these processes.

We determined the level of brain neurotrophic factor BDNF in plasma of adolescents aged 12-17 with syncopal conditions. Lower BDNF levels in plasma were found in a large number of adolescents examined. Taking into account the significant role of BDNF in the modulation of neuroplastic processes, the revealed decrease in its level can probably be regarded as a metabolic marker of the risk of neurodegenerative processes appearance and presence in brain tissue of adolescents with recurrent syncope. This assumption can be confirmed by further studies. Conclusions: syncopal conditions in adolescents are associated with a lower content of brain neurotrophic factor BDNF. In adolescents with syncopal conditions, there are more individuals with slightly or significantly lower BDNF compared to the group without syncope.

The pharmacological activity of the sum of phenolic compounds isolated from the multicomponent extract "Hexafeet", which has choleretic activity, and its role in the mechanism of action of this extract were studied. The positive effect of the sum of phenolic compounds on the cholate-forming, cholato-separation, antioxidant and membrane-stabilizing effect of "Hexafeet" extract in experiments on laboratory animals has been established.

The study examined the characteristics of the spectrum of sensitization to food and inhalant allergens in children of Khakassia with atopic dermatitis in combination with respiratory manifestations of allergies based on allergological history, objective examination data and skin testing results (prick-test). It is defined, that risk factors for the development of dermatorespiratory syndrome in children with upper respiratory tract damage or multiple organ respiratory tract damage may include: long course of the atopic dermatitis, manifestation of atopic dermatitis in the 1st year of life, aggravated heredity, pruritus, seasonality of the disease, high concentration of total IgE in blood serum, the presence of sensitization to food and pollen allergens, multivalent sensitization to milk, egg, cereals. Our study showed that the children of Khakassia have features of the sensitization spectrum depending on the expansion of the “shock” organs of atopy from atopic dermatitis to dermatorespiratory syndrome.

The article reports a case of pregnancy after in vitro fertilization using donor oocytes and delivery in a patient with Swyer syndrome.

The article presents the clinical and laboratory characteristics of Wiskott-Aldrich syndrome in a 2- month-old child. This is the first case of identifying such a patient in the Department of Oncohematology of the Pediatric Center of the Republican Hospital №1-National Center of Medicine (Yakutsk).

The article presents clinical observation of a family case of psoriasis complicated with a psoriatic arthritis. The described case sets up physicians' alertness with respect to psoriatic arthritis in differential diagnostics with such specific diseases as rheumatoid arthritis, gout. Active detection of patients with psoriatic arthritis requires first of all correct interpretation of anamnesis, clinical, laboratory and radiological data.