Lipoprotein lipase gene polymorphism rs320 and metabolic syndrome in native people of Yakutia
https://doi.org/10.25789/YMJ.2019.67.02
Abstract
The research objective was investigation the correlation of allelic variants and genotypes of the rs 320 polymorphism of the LPL gene with the metabolic syndrome and its components in adult population of the Yakut ethnic group. In the studied group it was not possible to establish a direct correlation between the allelic variants, the genotypes of the LPL rs320 gene with the metabolic syndrome and its components. However, it is important to note that individuals with the TT genotype had somewhat higher level of triglycerides in the blood. It may be associated with a small sample size. We assume that the T allele is associated with low enzyme activity in this population, and plays a key role in the development of diseases associated with metabolic disorders.
Keywords
obesity,
metabolic syndrome,
multiple metabolic risk factors,
population,
genetics,
rs320 polymorphism of the LPL gene,
dyslipidemia,
indigenous population,
Yakutia,
North
Supporting agencies: The study was supported by the Ministry of Education and Science of the Russian Federation (project “Clinical and genetic aspects of diseases characteristic of the indigenous people of Yakutia in modern conditions” (0794-2017-0016, FSRG-2017-0016)).
About the Authors
E. P. Ammosova
Research Center of the Medical Institute of the North-Eastern Federal University. M.K. Ammosov
Russian Federation
Russian Federation
Ammosova Elena Petrovna, candidate of Medical Sciences, leading researcher
677000, Moscow Yakutsk, str. Oiunskogo, 27, tel. 8-964-424- 39-08
T. M. Klimova
Medical Institute of the North-Eastern Federal University named after M.K. Ammosova;
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Klimova Tatyana Mikhailovna, candidate of Medical Sciences, assistant professor of Department of Pharmacology and Pharmacy;
senior researcher of the Department of Epidemiology of Chronic Non-Communicable Diseases
Moscow, Yakutsk, +79142336724
T. M. Sivtseva
Research Center of the Medical Institute of the North-Eastern Federal University. M.K. Ammosov
Russian Federation
Russian Federation
Sivtseva Tatyana Mikhailovna, cand. biol. sc., senior scientist
677000, Yakutsk, str. Oiunskogo, 27, tel. +7 914 223-74-32
A. I. Fedorov
Research Center of the Medical Institute of the North-Eastern Federal University. M.K. Ammosov
Russian Federation
Russian Federation
Fedorov Afanasy Ivanovich, cand. biol. science, senior researcher
677000, Yakutsk, str. Oiunskogo, 27, tel. 8-914-2332966
M. E. Baltakhinova
Research Center of the Medical Institute of the North-Eastern Federal University. M.K. Ammosov
Russian Federation
Russian Federation
Baltakhinova Marina Egorovna, junior researcher
677000, Yakutsk, str. Oiunskogo, 27, Tel. 89142710634
R. N. Zakharova
Research Center of the Medical Institute of the North-Eastern Federal University. M.K. Ammosov
Russian Federation
Russian Federation
Zakharova Raisa Nikolaevna, cand. med. science, scientific director
677000, Yakutsk, str. Oiunskogo, 27, tel. 8-914- 2223002
References
1. Metabolic syndrome in the aboriginal population of Yakutia / V.L. Osakovskij [et al.] // Yakut medical journal -. 2010. - №2 (30). – P. 98-102.
2. Osakovskij V.L. Lipoprotein lipase is an important genetic factor in the development of T2DM in the aboriginal population of Yakutia / V.L. Osakovskij, M.N. Yakovleva //Ibid. – 2011. - №3 (35). – P. 29-30.
3. Comparative characteristics of lipoprotein lipase gene variant LPL rs320 in different populations / T.M. Sivceva [et al.] //Ibid. – 2014. -№ 2 (46). – P.67-69.
4. Association of the HindIII and S447X polymorphisms in LPL gene with hypertension and type 2 diabetes in Mexican families / S. Munoz-Barriosa [et al.] // Disease Markers. – 2012. -№ 33. - P. 313–320.
5. DNA Polymorphisms of the Lipoprotein Lipase Gene and Their Association with Coronary Artery Disease in the Saudi Population / A. Al-Jafari [et.al.] // Int. J. Mol. Sci.- 2012. – 13. – P. 7559 – 7574.
6. Equilibrium Hardy-Weinberg [Online]. [cited 2017 June 15]. Available from: https://wpcalc.com/en/equilibrium-hardy-weinberg/.
7. Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease / Q. Chen [et al.] // Atherosclerosis. -2008. - № 1 (200). - P. 102-108.
8. Hind III polymorphism of the lipoprotein lipase gene and plasma lipid response to low calorie diet. / R. Jemaa [et al.] // Int J Obes Relat Metab Disord. – 1997. - № 4 (21) -P. 280–283.
9. Lipoprotein lipase gene polymorphisms as risk factors for stroke: a computational and meta-analysis / M. Nejati [et al.] //Iran J Basic Med Sci. – 2018.- 21(7). – P. 701-708.
10. Lipoprotein lipase gene polymorphism, cholesterol subfractions and myocardial infarction in large samples of the general population / Stephan R. Holmer [et al.] // Cardiovascular Research. – 2000. - № 47 –P. 806–812.
11. Polymorphisms of lipid metabolism enzyme-coding genes / Aslı Tetik Vardarlı [et al.] // Anatol J Cardiol. – 2017. - Vol. 17.-P. 313-321.
12. Seven Lipoprotein Lipase Gene Polymorphisms, Lipid Fractions, and Coronary / G. S. Sagoo [et al.] // American Journal of Epidemiology. - № 11 (168). - P. 1233-1246.
13. The Hind III polymorphism in the lipoprotein lipase gene predicts type 2 diabetes risk among Chinese adults / Qi. Yue [et al.] // Clinica Chimica Acta. -2011 - №13-14 (412).-P. 1229-1233.
14. The IDF consensus worldwide definition of the metabolic syndrome [Online]. 2006 [cited 2017 June 15]. Available from: https://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-themetabolic-syndrome.
15. The influence of lipoprotein lipase gene variation on postprandial lipoprotein metabolism / J. Lopez-Miranda [et al.] // J Clin Endocrinol Metab. -2004. -№9 (89). -P. 4721-4728.
16. Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease / Y.I. Ahn [et al.] // Journal of Lipid Research. -1993. – Vol. 34. –P.421-427.
17. Effects of lipoprotein lipase gene variations, a high-carbohydrate / Huang Xin [et al.] // BioScience Trends. -2011. -№5 (5). - P. 198-204.
Review
For citations:
Ammosova E.P., Klimova T.M., Sivtseva T.M., Fedorov A.I., Baltakhinova M.E., Zakharova R.N. Lipoprotein lipase gene polymorphism rs320 and metabolic syndrome in native people of Yakutia. Yakut Medical Journal. 2019;(3):9-12. https://doi.org/10.25789/YMJ.2019.67.02
Views:
4
Email this article 