ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2019.67.02ymj-988Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПолиморфизм RS 320 гена LPL и метаболический синдром у коренных жителей ЯкутииLipoprotein lipase gene polymorphism rs320 and metabolic syndrome in native people of Yakutiahttps://orcid.org/0000-0002-7973-6103АммосоваЕ. П.AmmosovaE. P.

Аммосова Елена Петровна ‒ к.м.н., в.н.с., доцент МИ СФВУ

Ammosova Elena Petrovna, candidate of Medical Sciences, leading researcher

677000, Moscow Yakutsk, str. Oiunskogo, 27, tel. 8-964-424- 39-08

ammosovael@mail.ruhttps://orcid.org/0000-0003-2746-0608КлимоваТ. М.KlimovaT. M.

Климова Татьяна Михайловна ‒ к.м.н., доцент МИ СВФУ, с.н.с.

Klimova Tatyana Mikhailovna, candidate of Medical Sciences, assistant professor of Department of Pharmacology and Pharmacy;

senior researcher of the Department of Epidemiology of Chronic Non-Communicable Diseases

Moscow, Yakutsk, +79142336724

biomedykt@mail.ruСивцеваТ. М.SivtsevaT. M.

Сивцева Татьяна Михайловна ‒ к.б.н., с.н.с.

Sivtseva Tatyana Mikhailovna, cand. biol. sc., senior scientist

677000, Yakutsk, str. Oiunskogo, 27, tel. +7 914 223-74-32

ФедоровА. И.FedorovA. I.

Федоров Афанасий Иванович ‒ к.б.н., с.н.с.

Fedorov Afanasy Ivanovich, cand. biol. science, senior researcher

677000, Yakutsk, str. Oiunskogo, 27, tel. 8-914-2332966

БалтахиноваМ. Е.BaltakhinovaM. E.

Балтахинова Марина Егоровна ‒ н.с.

Baltakhinova Marina Egorovna, junior researcher

677000, Yakutsk, str. Oiunskogo, 27, Tel. 89142710634

ЗахароваР. Н.ZakharovaR. N.

Захарова Раиса Николаевна ‒ к.м.н., в.н.с.

Zakharova Raisa Nikolaevna, cand. med. science, scientific director

677000, Yakutsk, str. Oiunskogo, 27, tel. 8-914- 2223002

НИЦ Медицинского института СВФУ им.М.К. АммосоваРоссияResearch Center of the Medical Institute of the North-Eastern Federal University. M.K. AmmosovRussian FederationНИЦ Медицинского института СВФУ им.М.К. Аммосова; ЯНЦ КМПРоссияMedical Institute of the North-Eastern Federal University named after M.K. Ammosova; Yakutsk Scientific Center for Complex Medical ProblemsRussian Federation20192408202503912Copyright © Аммосова Е.П., Климова Т.М., Сивцева Т.М., Федоров А.И., Балтахинова М.Е., Захарова Р.Н., 20252025Аммосова Е.П., Климова Т.М., Сивцева Т.М., Федоров А.И., Балтахинова М.Е., Захарова Р.Н.Ammosova E.P., Klimova T.M., Sivtseva T.M., Fedorov A.I., Baltakhinova M.E., Zakharova R.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/988

Целью исследования было изучение связи аллельных вариантов и генотипов полиморфизма rs 320 гена LPL с метаболическим синдромом и его компонентами у взрослого населения якутской национальности. В изученной группе не удалось установить прямой связи между аллельными вариантами, генотипами гена LPL rs320 с метаболическим синдромом и его компонентами. Но следует отметить, что уровень триглицеридов в крови был несколько выше у лиц с генотипом ТТ. Полученные данные, вероятно, связаны с ограниченным количеством выборки. Можно предположить, что в данной популяции аллель Т связан с низкой активностью фермента и играет ключевую роль в развитии заболеваний, связанных с метаболическими нарушениями.

The research objective was investigation the correlation of allelic variants and genotypes of the rs 320 polymorphism of the LPL gene with the metabolic syndrome and its components in adult population of the Yakut ethnic group. In the studied group it was not possible to establish a direct correlation between the allelic variants, the genotypes of the LPL rs320 gene with the metabolic syndrome and its components. However, it is important to note that individuals with the TT genotype had somewhat higher level of triglycerides in the blood. It may be associated with a small sample size. We assume that the T allele is associated with low enzyme activity in this population, and plays a key role in the development of diseases associated with metabolic disorders.

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The authors declare that there are no conflicts of interest present.