Genetics of Vilyui encephalomyelitis
Abstract
Viliuisk encephalomyelitis (VE) is a neurodegenerative disease with unknown etiology in development of which genetic factors have significant role. Study of HLA markers and other genes of immunity and analysis of exom sequencing in VE patients revealed features of the Yakut genome, predisposing to immunity dysfunction and functional insufficiency of proteolitic and phosphatase activity. In extreme environmental conditions these features may lead to dystrophic process development in the brain and distinguish type of encephalopathy as basis of VE pathogenesis.
About the Authors
T. M. Sivtseva
Institute of Health, NorthEastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Tatyana M. Sivtseva
Yakutsk
V. L. Osakovsky
Institute of Health, NorthEastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Vladimir L. Osakovsky
Yakutsk
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Review
For citations:
Sivtseva T.M., Osakovsky V.L. Genetics of Vilyui encephalomyelitis. Yakut Medical Journal. 2017;(3):55-57.
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