Polymorphism of genes localized on the X-chromosome as a marker of predisposition to infectious process chronicity at hepatitis C in the ethnic group of male Yakuts
https://doi.org/10.25789/YMJ.2019.66.19
Abstract
The work studied variable sites of six genes localized on the X-chromosome in the Yakut ethnic group. The candidate TLR7 rs179009 gene was found, the C-allele of which is associated with the chronic course of hepatitis C. The minor C allele is more than 2 times more common in patients with chronic hepatitis C than in the group with spontaneous recovery. It was found that the chances of hepatitis transition to a chronic course is 2.7 times higher in carriers of the C-allele than in carriers of the T-allele rs179009 TLR7. The obtained data confirm the possible significance of the rs179009 polymorphism of the TLR7 gene as a genetic marker of predisposition to the chronicity of the infectious process while viral hepatitis C in the ethnic group of male Yakuts.
Keywords
hepatitis C,
single nucleotide polymorphisms,
toll-like receptors,
X chromosome,
chronic infection process,
Yakuts,
male
Supporting agencies: This work was supported by the RFBR grant № 18-415-140001.
About the Authors
S. S. Sleptsova
Northeastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Sleptsova Snezhana Spiridonovna - Doctor of Medical Sciences, Associate Professor, Head of the Department of Infectious Diseases, Phthisiology and Dermatovenereology of the Medical Institute, tel. 8-914-2718770
677010, Yakutsk, ul. Oiunsky, 27
I. F. Bilyukina
Northeastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Bilyukina Iraida Fedoseyevna - full-time graduate student of the Department of Infectious Diseases, Phthisiology and Dermatovenereology of the Medical Institute, tel. 8-962- 7321207
677010, Yakutsk, ul. Oyunskogo, 27
S. I. Malov
Irkutsk State Medical University
Russian Federation
Russian Federation
Malov Sergey Igorevich, PhD, Assistant Professor, Department of Infectious Diseases
Irkutsk
S. I. Semenov
Northeastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
Semenov Sergey Innokentievich - doctor of medical sciences, leading researcher of SIC, tel. 8-914-2862948
L. A. Stepanenko
Irkutsk State Medical University
Russian Federation
Russian Federation
Stepanenko Liliya Alexandrovna - PhD, Senior Lecturer Research Institute of Biomedical Technologies,
Irkutsk
O. B. Ogarkov
Research Center for Family Health and Human Reproduction
Russian Federation
Russian Federation
Ogarkov Oleg Borisovich - Ph.D. Department of Epidemiology and Microbiology
Irkutsk
E. D. Savilov
Research Center for Family Health and Human Reproduction
Russian Federation
Russian Federation
Savilov Evgeniy Dmitrievich - doctor of medical sciences, professor, chief researcher of the department of epidemiology and microbiology
Irkutsk
I. V. Malov
Irkutsk State Medical University
Russian Federation
Russian Federation
Malov Igor Vladimirovich - Doctor of Medical Sciences, Professor, Head of the Department of Infectious Diseases
Irkutsk
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Review
For citations:
Sleptsova S.S., Bilyukina I.F., Malov S.I., Semenov S.I., Stepanenko L.A., Ogarkov O.B., Savilov E.D., Malov I.V. Polymorphism of genes localized on the X-chromosome as a marker of predisposition to infectious process chronicity at hepatitis C in the ethnic group of male Yakuts. Yakut Medical Journal. 2019;(2):64-67. https://doi.org/10.25789/YMJ.2019.66.19
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