Immunogenetic markers of the Siberia southern regions’ population under the exposure of technogenous factors
https://doi.org/10.25789/YMJ.2019.66.15
Abstract
A laboratory immunological and genetic examination of the adult population living in the zone of the combined effects of a number of chemical environmental factors was carried out. There was a significant decrease in the number of CD3 +CD25+- lymphocytes relative to the reference interval, and there were lower concentrations of CD16+CD56+ -, CD3+- and CD4+-cells relative to the comparison group. The decrease in serum IgG and IgM levels was combined with an increase in the level of IgG to aluminium and benzo(a)pyrene, IgE to formaldehyde relative to the values in the comparison group. There was a significant (p=0.02) increase in the frequency of occurrence of the minor allele of the enzyme eNOS rs1799983 gene associated with a decrease in serum levels of nitric oxide, which indicates the formation of additional risk factors under technogenic exposure.
About the Authors
O. V. Dolgikh
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Russian Federation
Russian Federation
Oleg V. Dolgikh, PhD, MD (Medicine), Professor, Head of the department of immunobiological diagnostic methods
82, Monastyrskaya St., Perm, 614045
phone: +7(342)2363930
K. G. Starkova
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Russian Federation
Russian Federation
Ksenia G. Starkova, PhD (Biology), Head of the laboratory of immunology and allergology
82, Monastyrskaya St., Perm, Russia, 614045
phone: +7(342)2368699
A. V. Krivtsov
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Russian Federation
Russian Federation
Aleksandr V. Krivtsov ,PhD (Medicine), Head of the laboratory of immunogenetics
82, Monastyrskaya St., Perm, 614045
phone: +7(342)2368699
O. A. Kazakova
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Russian Federation
Russian Federation
Olga A. Kazakova, junior researcher of the laboratory of immunogenetics
82, Monastyrskaya St., Perm, Russia, 614045
phone: +7(342)2363930
A. A. Mazunina
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Russian Federation
Russian Federation
Alena A. Mazunina, junior researcher of the laboratory of immunogenetics
82, Monastyrskaya St., Perm, Russia, 614045
phone: +7(342)2363930
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Review
For citations:
Dolgikh O.V., Starkova K.G., Krivtsov A.V., Kazakova O.A., Mazunina A.A. Immunogenetic markers of the Siberia southern regions’ population under the exposure of technogenous factors. Yakut Medical Journal. 2019;(2):53-56. https://doi.org/10.25789/YMJ.2019.66.15
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