The diagnostics and treatment of endogenous intoxication in patients with mandibletraumatic osteomyelitis
https://doi.org/10.25789/YMJ.2019.66.13
Abstract
We determine the diagnostic efficiency of laboratory parameters in endotoxicosis caused by traumatic osteomyelitis of the lower jaw, as well as the development of a diagnostic algorithm and complex treatment depending on the stage of chronic endogenous intoxication. Patients with traumatic osteomyelitis of the lower jaw at the age of 18 to 65 years were examined. As a result of the study, it was found that the most informative in the prognostic plan is the definition of the level of “medium-mass molecules”, diene conjugates and the sorption capacity of erythrocytes. Other parameters investigated, including integral leukocyte indices of intoxication, are inferior to them for diagnostic value.
About the Authors
E. V. FomichevRussian Federation
Fomichev Evgeniy Valentinovich - Doctor of Medical Sciences, Professor, Head of the Department of Surgical Dentistry and Maxillofacial Surgery
Volgograd, 400081, st. Angarskaya 7B – 44
89375541234
L. D. Weisheim
Russian Federation
Weisheim Lyudmila Dmitrievna - doctor of medical sciences, professor, head of the chair
Volgograd, 400117, st. Sheksninskaya 40-77, 89272512731
M. V. Kirpichnikov
Russian Federation
Kirpichnikov Mikhail Viktorovich - Candidate of Medical Sciences, Associate Professor of the Department of Oral and Maxillofacial Surgery
Volgograd, 400081, st. Tvardovsky 10-55, 89026592098
E. N. Yarygina
Russian Federation
Yarygina Elena Nikolaevna - Candidate of Medical Sciences, Associate Professor of the Department of Oral and Maxillofacial Surgery
Volgograd, 400131, Lenin Avenue 15-73, 89272512731
A. V. Mikhalchenko
Russian Federation
Mikhalchenko Aleksey Valerevich - Candidate of Medical Sciences, Associate Professor of the Department of Therapeutic Stomatology
Volgograd, 400005, Lenin Avenue 68-33, 89023625065
A. V. Yurkevich
Russian Federation
Yurkevich Alexander Vladimirovich - doctor of medical sciences, associate professor, head of Department of orthopedic stomatology
Khabarovsk, 680000, st.Muravieva-Amurskogo 35-233
89655025888
I. D. Ushnitsky
Russian Federation
Ushnitsky Innokenty Dmitrievich - doctor of medical sciences, professor, head of the Department of therapeutic, surgical, orthopedic dentistry and pediatric dentistry
Yakutsk, 677000,st.Oyunsky 27-420
89241708940
References
1. Kirpichnikov M.V. Efficiency of complex treatment of traumatic osteomyelitis of the lower jaw with the use of efferent methods: author’s abstract. dis. ... cand.med. sciences / M.V. Kirpichnikov. ‒ Volgograd, 2004. - 22 p. http://www.dissercat.com/content/effektivnost-kompleksnogo-lecheniya-travmaticheskogo-osteomielita-nizhnei-chelyusti-s-primen
2. Kirpichnikov M.V. Complex diagnostics of endogenous intoxication in patients with chronic and atypically ongoing purulent-inflammatory diseases of face and neck / M.V. Kirpichnikov, E.N. Yarygina // Medical alphabet. - 2008. - V.2, №5 (Stomatology). - P. 20-22.https://elibrary.ru/item.asp?id=30693176
3. Medical laboratory diagnostics: programs and algorithms. A guide for doctors / ed. prof. A.I. Karpischenko. - 3rd ed., rewr. and add. - M.: GEOTAR-Media, 2014. - 692 p. https://elibrary.ru/item.asp?id=25874190
4. Ostrovsky V.K. Leukocyte index of intoxication and some blood counts in assessing the severity of the course and determining the prognosis of inflammatory, purulent and purulent-destructive diseases of different localizations / V.K. Ostrovsky, A.V. Mashchenko, D.V. Yangolenko, S.V. Makarov // Anesthesiology and resuscitation. - 2005. - №6. - P.25-29. https://elibrary.ru/item.asp?id=9295730
5. Modern features of clinical manifestations of odontogenic and traumatic osteomyelitis of the lower jaw / E.V. Fomichev, M.V. Kirpichnikov, E.N. Yarygina // Bulletin of VolgGMU. - 2013. - №.1 (45). - Р.7-11.http://www.volgmed.ru/uploads/journals/articles/1524479622-bulletin-2017-4-3135.pdf
6. Fletcher R. Clinical Epidemiology. Basics of Evidence-Based Medicine: Trans. from English / R. Fletcher, S. Fletcher, E. Wagner - M., 1998. - 352 p. http://kingmed.info/knigi/Infektsionnye_bolezni_Epidemiologia/book_3455/Klinicheskaya_epidemiologiya_Osnovi_dokazatelnoy_meditsini-Fletcher_R_Fletcher_S_Vagner_E_-1998-pdf
7. Fomichev E.V. Analysis of the etiological factors of traumatic osteomyelitis of the lower jaw / E.V. Fomichev, M.V. Kirpichnikov, V.V. Podolsky // Volgograd Scientific Medical Journal. - 2010. - №4. - P.41-44. https://readera.ru/analiz-jetiologicheskih-faktorov-travmaticheskogo-osteomielita-nizhnej-cheljusti-142148866
8. Fomichev E.V. Effectiveness of treatment of patients with traumatic osteomyelitis of the lower jaw by means of efferent methods / E.V. Fomichev, O.V. Ostrovsky, M.V. Kirpichnikov // Volgograd Scientific Medical Journal. - 2010. - №3. - P.42-45. https://cyberleninka.ru/article/n/effektivnost-lecheniya-bolnyh-travmaticheskim-osteomielitom-nizhney-chelyusti-s-pomoschyu-efferentnyh-metodov
9. Yarygina E.N. Diagnosis of endogenous intoxication in patients with atypically flowing phlegmon and maxillofacial area and traumatic osteomyelitis of the lower jaw / E.N. Yarygina, E.V. Smotrova, M.V. Kirpichnikov // Bulletin of the Russian State Medical University. - 2006. - №2. - P. 202. https://cyberleninka.ru/article/n/sovremennye-osobennosti-klinicheskih-proyavleniy-odontogennogo-i-travmaticheskogo-osteomielita-nizhney-chelyusti
10. Mihara M. Thiobarbituric acid value on fresh homogenate of rat as a parameter of lipid peroxidation in aging, CCl4 intoxication and vitamin E deficiency / M. Mihara, M. Uchiyama, K. Fukuzawa // Biochem. Med. ‒ 1980. ‒ V. 23. ‒ №3. ‒ P. 302–311. https://www.ncbi.nlm.nih.gov/pubmed/7417237
11. Prieto P. Spectrophotometric Quantitation of Antioxidant Capacity through the Formation of a Phosphomolybdenum Complex: Specific Application to the Determination of Vitamin E / P.Prieto, M. Pineda, M. Aguilar //Anal Biochem https://www.ncbi.nlm.nih.gov/pubmed/102220071999;269:337-41pubmed/102220071999;269:337-41
Review
For citations:
Fomichev E.V., Weisheim L.D., Kirpichnikov M.V., Yarygina E.N., Mikhalchenko A.V., Yurkevich A.V., Ushnitsky I.D. The diagnostics and treatment of endogenous intoxication in patients with mandibletraumatic osteomyelitis. Yakut Medical Journal. 2019;(2):45-48. https://doi.org/10.25789/YMJ.2019.66.13