Assessment of the contribution of environmental factors and interleukin-10 gene polymorphisms to the formation of its serum levels
https://doi.org/10.25789/YMJ.2019.66.03
Abstract
The contribution of chemical inhalation load and polymorphisms of the gene of interleukin-10 to the formation of its serum levels in adolescents was studied. The polymorphic variants -1082G / A, -592C / A, -819C / T of the IL-10 gene and the content of its protein product in the blood were studied in schoolchildren, living under conditions of different levels of air pollution. It has been established that air pollution by immunotropic compounds plays the dominant role in the formation of the serum level of IL-10 in healthy adolescents. The effect of the polymorphic loci 592C / A, -819C / T of the IL-10 gene on the formation of its level is manifested in conditions of high inhalation chemical load.
About the Author
L. B. Masnavieva
East-Siberian Institute of Medical and Ecological research
Russian Federation
Russian Federation
Masnavieva Liudmila Borisovna., Sc.D., senior researcher of immunological, biochemical, molecular and genetic researches in hygiene
References
1. Belik V.P. The adaptation of methods for isolating DNA from frozen blood / V.P. Belik, I.V. Kudaeva, L.B. Masnavieva // Medical alphabet. Modern Lab. – 2014. – Vol. 1, № 2. – P. 36-38.
2. Research of the role of polymorphic options of interleukins genes in development of asthma in the Yakut population / N.A. Solovyova, Kh.A. Kurtanov, N.I. Pavlova [et al.] // Yakut medical journal. – 2018. – № 1. – P. 8-10.
3. Complex assessment of clinical features and role of interleukin-10 G-1082A gene polymorphism in the development of slowly resolving clinical course of community-acquired pneumonia / V.I. Sovalkin, E.G. Pomorgaylo, O.N. Sabitova [et al.] //Kazan medical journal. – 2013. – № 4. – Р. 438-444.
4. Masnavieva L.B. Individual risks to adolescent health, caused by contaminating the air, and their relationship with the levels of specific autoantibodies / L.B. Masnavieva, N.V. Efimova, I.V. Kudaeva // Hygiene and sanitation. – 2016. – № 8. – Р. 738–743. DOI: 10.18821/0016-9900-2016-95-8-738-742.
5. Otavina E.A. Changes of immune regulatory indicators at children in the conditions of an exposition strontium / E.A. Otavina, O.V. Dolgych // Russian Journal of Immunology. – 2017. – Vol. 11(20), № 2. - Р. 188-191.
6. Polymorphisms of the Anti-Inflammatory IL-10 Gene Associated with Malignancy in Female Reproductive System / A.R. Tuguz, E.N. Anokhina, D.V. Muzhenya [et al.]// Bulletin of Experimental Biology and Medicine. – 2014. – № 11. – P.624-626.
7. Human health risks assessment from environmental chemicals. R2.1.10.1920-04. – M.: Federal Center for Gossanepidnadzor of the Ministry of Health of Russia, 2004. - 143 p.
8. Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children / O. Gruzieva, S.K. Merid, A. Gref [et al.] // Environ Health Perspect. – 2017. – Vol. 25, N 6. – P. 067007. doi: 10.1289/EH.P460.
9. Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population / S. Mohammadi, J.M.Saghaeian, E.M. Zare [et al.]. // Int J Immunogenet. – 2019. – Vol. 46, N 1. – P. 20-30. DOI: 10.1111/iji.12407.
10. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Molgora M, Bonavita E, Ponzetta A [et al.] // Nature. – 2017. – N 551(7678). – P. 110-114. DOI: 10.1038/nature24293
11. Interleukin10-1082 A/G polymorphism: Allele frequency, correlation with disease markers, messenger RNA and serum levels in North Indian rheumatoid arthritis patients / M. Jahid, Rehan-Ul-Haq, R. Avasthi [et al.] // Clin Biochem. – 2018. – N 55/ – P.80-85. DOI: 10.1016/j.clinbiochem.2018.03.024.
12. Lacrimal Cytokines Assessment in Subjects Exposed to Different Levels of Ambient Air Pollution in a Large Metropolitan Area / M. Matsuda, R. Bonatti, M.V. Marquezini [et al.] // PLoS One. – 2015. – Vol. 10, N 11. – P. e0143131. DOI: 10.1371/journal.pone.0143131.
13. Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer / D.M. Cárdenas, A.C. Sánchez, D.A. Rosas [et al.] // BMC Gastroenterol. – 2018. – Vol. 18, N 1. – P. 184. DOI: 10.1186/s12876-018-0913-9.
Review
For citations:
Masnavieva L.B. Assessment of the contribution of environmental factors and interleukin-10 gene polymorphisms to the formation of its serum levels. Yakut Medical Journal. 2019;(2):14-17. https://doi.org/10.25789/YMJ.2019.66.03
Views:
3
Email this article 