Epidemiology of Parkinson’s disease in the RS(Ya)

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the world after Alzheimer’s disease. The prevalence of the disease varies widely in different ethnic and geographical groups. The purpose of the research is to study the epidemiological picture of PD in the population of the Sakha (Yakutia) Republic. We used the next sources of information: 1) own data collected during the examination of patients; 2) retrospective analysis of medical records about patients of the neurological department; 3) data from annual reports of neurologists; 4) the results of selective population studies conducted by the Department of neurology and psychiatry of Medical Institute of NEFU. All information was entered in the database «Register of patients with Parkinson’s disease in the Sakha (Yakutia) Republic». The prevalence of PD in Yakutia was 67 per 100,000 of the adult population. The disease was more common in women than in men: 79.7 versus 52.9 per 100,000. The prevalence of the disease in Yakutsk was 76.5 per 100,000 population, and in the regions it varied widely from 9.8 to 185.6 per 100,000 population. The highest frequency of PD was found in the central regions (Gorny, Khangalassky), in the regions of the Vilyui group (Vilyuisky and Verkhnevilyuisky), as well as in Tattinsky, Abyisky, Verkhnekolymsky and Lensky regions. The prevalence of PD increased in the older age groups: in the 40-49 age group this parameter was 12.9 per 100,000, and in the 70 years and older group it was 527.5 per 100,000. We did not reveal statistical differences in prevalence of PD among the Yakut (75.4 per 100,000) and Russian (73.4 per 100,000) population. The incidence of PD persists at a low level, but over the past 5 years, there has been a tendency to increase it: if in 2011 it was 1.42 per 100,000, in 2016 it would be 3.86 per 100,000 population. Thus, we conducted an epidemiological study of PD in Yakutia for the first time, identified regional features, found that the disease with the same frequency occurs in the Yakut and Russian population.