Pathomorphological and pathophysiological evaluation of liver changes in white rats with experimental dyslipidemia and its correction
Abstract
In the experiment, a morphofunctional assessment of liver changes in rats with dyslipidemia and its phytotherapeutic correction was performed. It was found that the appointment of an atherogenic diet is accompanied by an increase in the total blood cholesterol, triglycerides, low density lipoproteins cholesterol and a decrease in the level of high density lipoproteins cholesterol. Against this background, the liver develops pathomorphological changes in the form of fatty hepatosis, necrobiosis and circulatory disorders. In addition, an increase in malonic dialdehyde concentration and inhibition of catalase activity are observed in rats liver homogenates. At the same time, the course introduction of phytoremedy normalizes the lipid metabolism, raises the activity of catalase in liver homogenates and reduces the content of malonic dialdehyde, and also reduces the severity of pathomorphological changes in the liver. Apparently, the polyvalent effect of phytoremedy is due to the content in its components of a complex of biologically active substances that exert lipid-lowering, antioxidant and hepatoprotective effects.
About the Authors
V. G. Banzaraksheev
Medical Institute Buryat State University
Russian Federation
Russian Federation
Banzaraksheev Vitaly Gambalovich - candidate of medical sciences, associate professor department of human general pathology
670002, Ulan-Ude, Oktyabrskaya, str., 36a
Ya. G. Razuvaeva
Institute of General and Experimental Biology SB RAS
Russian Federation
Russian Federation
Razuvaeva Yanina Gennadyevna – doctor of biological sciences, Senior Research Officer of the Laboratory of Biologically Active Substances Safety
670047, Ulan-Ude, Sakhyanova str., 6
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Review
For citations:
Banzaraksheev V.G., Razuvaeva Ya.G. Pathomorphological and pathophysiological evaluation of liver changes in white rats with experimental dyslipidemia and its correction. Yakut Medical Journal. 2017;(3):85-88.
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