Stress-protective activity of the extract of Fornicium uniflorum L.
Abstract
The results of studies on the adaptogenic properties of Fornicium uniflorum L. extracts has been given in the present article. The aim of the study was to evaluate stress-protective activity of extracts from Fornicium uniflorum L. at immobilization stress in white rats. The dry extract from Fornicium uniflorum rhizomes has stress protective properties in 18-hour immobilization stress simulated in white rats. It has been revealed that the given plant remedy prevents from the development of the “Selye’s triad” signs: hypertrophy of renal glands, involution of immune competent organs (thymus and spleen), as well it prevents heavy destructions in the stomach mucosa of white rats. It has been established that the stressprotective effect of the tested plant remedy is due to its inhibiting influence in the processes of free radical oxidation that is testified by the decrease in the concentration of TBA-active products. The antioxidant activity of the Fornicium uniflorum extract is due to the capacity of phytoecdysteroids and phenolic compounds contained in the plant, to render the direct antiradical effect, as well to increase the activity of the endogen antioxidant system of the defence in the animals.
About the Authors
L. N. Shantanova
Institute of General and Experimental Biology SB RAS
Russian Federation
Russian Federation
Shantanova Larisa Nikolaevna, doctor of biological sciences, professor, head of the laboratory of safety of biologically active substances
Ulan-Ude, ul. Sahyanovoy, 6.
S. M. Nikolaev
Institute of General and Experimental Biology SB RAS
Russian Federation
Russian Federation
Nikolaev Sergey Matveevich, doctor of medicine sciences, Chief Researcher
Ulan-Ude, ul. Sahyanovoy, 6.
I. E. Mathanov
Russian Research Centre for Medical Rehabilitation and Balneology, Russian Ministry of Health
Russian Federation
Russian Federation
Matkhanov Irinchey Eduardovich, Candidate of Medical Sciences Senior Researcher
ul. Novy Arbat, Moscow, 121099
S. M. Gulyaev
Institute of General and Experimental Biology SB RAS
Russian Federation
Russian Federation
Gulyaev Sergey Mirinovich, Candidate of Medical Sciences Senior Researcher
Ulan-Ude, ul. Sahyanovoy, 6.
N. K. Tatarinova
Institute of General and Experimental Biology SB RAS
Russian Federation
Russian Federation
Tatarinova Natalya Konstantinovna, graduate student of the laboratory experimental pharmacology
Ulan-Ude, ul. Sahyanovoy, 6.
B. A. Muruyev
Institute of General and Experimental Biology SB RAS
Russian Federation
Russian Federation
Muruev Bair Andreevich, graduate student of the laboratory experimental pharmacology
Ulan-Ude, ul. Sahyanovoy, 6.
V. G. Banzaraksheev
Buryat State University
Russian Federation
Russian Federation
Banzaraksheev Vitaly Gambalovich, Candidate of Medical Sciences, Senior lecturer
Ulan-Ude, 670000, ul. Smolina, 24a
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Review
For citations:
Shantanova L.N., Nikolaev S.M., Mathanov I.E., Gulyaev S.M., Tatarinova N.K., Muruyev B.A., Banzaraksheev V.G. Stress-protective activity of the extract of Fornicium uniflorum L. Yakut Medical Journal. 2017;(3):80-82.
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