ALA54THR polymorphism of the FABP2 gene and metabolic syndrome in the Yakut population
Abstract
We analyzed association of allelic rs1799883 options (FABP2) with metabolic syndrome and its components at representatives of the Yakut ethnic group (on self-determination) from Berdigestyakh village of the Gorniy region of Republic Sakha (Yakutia). The association of genotype AG with abdominal obesity was established at OR 1,7 (95% CI 1,01-2,99).
About the Authors
T. M. KlimovaRussian Federation
R. N. Zakharova
Russian Federation
A. I. Fedorov
Russian Federation
M. E. Baltakhinova
Russian Federation
E. P. Ammosova
Russian Federation
V. I. Fedorova
Russian Federation
References
1. Kaznacheev V.P. Adaptation and human constitution / V.P. Kaznacheev, S.V. Kaznacheev; Ed. N.R. Deryapa. – Novosibirsk: Science, 1986. – 118 p.
2. Klimova T.M. Obesity criteria for identifying metabolic risk factors among indigenous rural population of Yakutia / T.M. Klimova, V.I. Fedorova, M.E. Baltakhinova // Siberian Medical Journal (Irkutsk). – 2012. – № 8 (115). – P. 110–113.
3. Panin L.E. Homeostasis and problems of circumpolar health (methodological aspects of adaptation) / L.E. Panin // The Bulletin of Siberian Branch of Russian Academy of Medical Sciences. – 2010. – № 3 (30). – P. 6–11.
4. Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus / Abbas S. [et al.] // Journal of Biomedical Science. – 2013. – № 1 (20). – C. 80.
5. FABP2 fatty acid binding protein 2 [Online]. [cited 2017 June 15]. Available from: https://www.ncbi.nlm.nih.gov/gene/2169
6. FABP2 Gene (Protein Coding) [Online]. [cited 2017 June 15]. Available from: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FABP2
7. Equilibrium Hardy-Weinberg [Online]. [cited 2017 June 15]. Available from: https://wpcalc.com/en/equilibrium-hardy-weinberg/
8. IDF. The IDF consensus worldwide definition of the metabolic syndrome [Online]. 2006 [cited 2017 June 15]. Available from: https://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-themetabolic-syndrome
9. Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits / Kristiansson K. [et al.] // Circulation: Cardiovascular Genetics. – 2012. – № 2 (5). – P. 242–249.
10. Gene polymorphisms of FABP2, ADIPOQ and ANP and risk of hypertriglyceridemia and metabolic syndrome in Afro-Caribbeans / Larifla L. [et al.] // PLoS ONE. – 2016. – № 9 (11). – P. 1–14.
11. Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based casecontrol study and a systematic meta-analysis / Liu Y. [et al.] // Genetics and Molecular Research. – 2015. – № 1 (14). – P. 1155–1168.
12. The Metabolic Syndrome and Cardiovascular Risk /Mottillo S. [et al.] // Journal of the American College of Cardiology. – 2010. – № 14 (56). – P. 1113–1132.
13. Association between FABP2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: A HuGE Review and Meta-Analysis /Qiu C.J. [et al.] // Journal of Cellular and Molecular Medicine. – 2014. – № 12 (18). – P. 2530–2535.
14. The Ala54Thr polymorphism of the fatty acid binding protein 2 gene modulates HDL cholesterol in Mexican-Americans with type 2 diabetes / Salto L.M. [et al.].// International Journal of Environmental Research and Public Health. – 2015. – № 1 (13). – P. 1–10.
15. Stancakova A. Genetics of metabolic syndrome / A. Stancakova, M. Laakso // Reviews in Endocrine and Metabolic Disorders. – 2014. – № 4 (15). – P. 243–252.
16. Zhao T. Association of the fatty acid-binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a metaanalysis in 13451 subjects / T. Zhao, J. Zhao, W. Yang // Diabetes/Metabolism Research and Reviews. – 2010. – № 5 (26). – P. 357–364.
Review
For citations:
Klimova T.M., Zakharova R.N., Fedorov A.I., Baltakhinova M.E., Ammosova E.P., Fedorova V.I. ALA54THR polymorphism of the FABP2 gene and metabolic syndrome in the Yakut population. Yakut Medical Journal. 2017;(3):24-27.