Allelic polymorphism of the serotonin transporter as a formation factor of the behavioral cognitive control in the Yakuts
Abstract
The effects of allelic polymorphisms of serotonin transporter (5-HTT) on behavioral reactions and EEG-responses in the stop-signal paradigm (SSP) were compared in the Russian and Yakut participants. It was revealed that the frequency of occurrence of the S-allele of the 5-HTT gene in the Yakuts was significantly higher (73%), than that in the Russians (39%). In the behavioral SSP measures, the SS genotype was associated with the higher indexes of the motor control in comparison with LL genotype. In EEG responses, the people with SS genotype showed shorter reactions in alpha frequency band in comparison with the people with LL genotype. Hypothetically, the genotype of SS gives the advantages for adaptation to environmental conditions, connected with a need to make decisions under a time deficiency, however it could be a disadvantage factor in the conditions demanding long concentration of attention during task execution.
About the Authors
A. G. KarpovaRussian Federation
A. N. Savostyanov
НИИ физиологии и фундаментальной
медицины
Russian Federation
Russian Federation
D. V. Bazovkina
НИИ физиологии и фундаментальной медицины
Russian Federation
Russian Federation
S. S. Tamozhnikov
НИИ физиологии и фундаментальной медицины
Russian Federation
Russian Federation
A. E. Saprygin
НИИ физиологии и фундаментальной медицины
Russian Federation
Russian Federation
E. A. Proshina
НИИ физиологии и фундаментальной медицины
Russian Federation
Russian Federation
N. V. Borisova
Russian Federation
L. I. Aftanas
НИИ физиологии и фундаментальной медицины
Russian Federation
Russian Federation
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Review
For citations:
Karpova A.G., Savostyanov A.N., Bazovkina D.V., Tamozhnikov S.S., Saprygin A.E., Proshina E.A., Borisova N.V., Aftanas L.I. Allelic polymorphism of the serotonin transporter as a formation factor of the behavioral cognitive control in the Yakuts. Yakut Medical Journal. 2017;(3):21-24.
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