Investigation of the role of phenolic compounds in the mechanism of action of the new agent for prevention and treatment of digestive diseases
https://doi.org/10.25789/YMJ.2020.70.28
Abstract
The pharmacological activity of the sum of phenolic compounds isolated from the multicomponent extract "Hexafeet", which has choleretic activity, and its role in the mechanism of action of this extract were studied. The positive effect of the sum of phenolic compounds on the cholate-forming, cholato-separation, antioxidant and membrane-stabilizing effect of "Hexafeet" extract in experiments on laboratory animals has been established.
About the Author
E. V. FerubkoRussian Federation
Ferubko Ekaterina Vladimirovna – PhD (candidate of medical sciences), head of the department of experimental and clinical pharmacology
Greene St., 7. Moscow, 117216
References
1. Borovikov V.P. A popular introduction to modern data analysis in the STATISTICA system / V.P. Borovikov. – M.: Hot line. Telekom, 2014. – 288 р.
2. Bueverov A.O. Liver damage with drugs / A.O. Bueverov // Russian medical journal. – 2012. - № 3. – Р. 107-110.
3. Vladimirov Yu.A. Free radicals and antioxidants / Yu.A. Vladimirov // RAMN Herald. - 1988. - №7. - Р. 43-50.
4. State register of medicines. URL https://grls.rosminzdrav.ru/ (accessed on 07.01.2020)
5. Lubsandorzhieva P.-N.B. Development and standardization of herbal medicines for the treatment and prevention of digestive diseases / P.- N.B. Lubsandorzhieva. – Ulan-Ude: Izd-vo BNC SO RAN, 2016. – 280 р.
6. Nikolaev S.M. Phytopharmacotherapy and disease phytopharmacoprophylaxis / S.M. Nikolaev. – Ulan-Ude: Izd-vo BGU, 2012. –286 р.
7. Guidelines for preclinical studies of drugs. Part 1. - M.: Grif & Co, 2012. – 944 р.
8. Ferubko E.V. Agent with choleretic activity and method for its preparation. Patent 2700681 of the Russian Federation / E.V. Ferubko, S.M. Nikolaev, T.D. Dargaeva //Bulletin № 26. Decl. 13.06.2019, publ. 19.09.2019.
9. Cimmerman Ya. S. Unresolved and controversial issues of modern gastroenterology / Ya. S. Cimmerman. – M.: MEDpress-inform, 2013. – 224 р.
10. Folch J. A simple method for the isolation and purification of total lipids from animal tissues / J. Folch, M. Less, A.G.H. Sloane-Stanley // Journal of Biological Chemistry. – 1957. – Vol. 226. – P. 497–509.
11. Hirschfield G.M. Pathogenesis of cholestatic liver disease and therapeutic approaches / G.N. Hirschfield, E.J. Heathcote, M.E. Gershwin // Gastroenterology. – 2010. – Vol. 139. – P. 1481 - 1496. doi: 10.1053/j.gastro.2010.09.004.
12. Medicinal plants with hepatoprotective activity in Iranian folk medicine / M.A. Samani, N. Kafash-Farkhad, N. Azimi [et. al.] // Asian Pacific Journal of Tropical Biomedicine. – 2015. – Vol. 5. – P. 146 - 157.
13. Natural products: perspectives in the pharmacological treatment in gastrointestinal anisakiasis / A. Valero, M.C. Romero, M. Gomez-Mateos [et. al.] // Asian Pacific Journal of Tropical Medicine. – 2015. – Vol. 8. – P. 612-617. doi: 10.1016/j.apjtm.2015.07.017.
14. Zhang A. Recent advances in natural products from plants for treatment of liver diseases / A. Zhang, H. Sun, X. Wang // European Journal of Medicinal Chemistry. – 2013. – Vol. 63. – P. 570 - 577.
Review
For citations:
Ferubko E.V. Investigation of the role of phenolic compounds in the mechanism of action of the new agent for prevention and treatment of digestive diseases. Yakut Medical Journal. 2020;(2):96-98. https://doi.org/10.25789/YMJ.2020.70.28