The role of matrix metalloproteinases and their inhibitors in patients with local cold injury
https://doi.org/10.25789/YMJ.2020.70.22
Abstract
A study was carried out to determine the dynamics of collagenase levels of the second subfamily (MMR-2, MMR-9) and their inhibitors (TIMP1 and TIMP-2) in blood of patients with local cold injury (LCI). It was found out that in patients with LCI the level of MMR-2 and MMR-9 in serum increases with respect to the control group in the early period of cryodamage, and also the indices of the studied markers increase directly proportional to the volume of the affected tissues. The same dynamics was observed in the study of matrix metalloproteinase inhibitors parameters. On the basis of the obtained data and analysis of the linear regression equation a prognostic model was formed, which allows to suspect with high accuracy the level of tissue affection in the early terms of local cold injury.
About the Authors
M. I. Mikhailichenko
Chita State Medical Academy
Russian Federation
Russian Federation
Mikhailichenko Maxim I. – Assistant of department of faculty surgery with the course of urology
Phone number: +79145222922
39a, Gorky street, Chita, 672000
K. G. Shapovalov
Chita State Medical Academy
Russian Federation
Russian Federation
Shapovalov Konstantin G. – Head of the Department of anesthesiology, intensive care. DM, professor
39a, Gorky street, Chita, 672000
V. A. Mudrov
Chita State Medical Academy
Russian Federation
Russian Federation
Mudrov Viktor A. – Associate professor of obstetrics and gynecology
39a, Gorky street, Chita, 672000
O. S. Grusdeva
Chita State Medical Academy
Russian Federation
Russian Federation
Grusdeva Olga S. – Assistant of the Department of pathological anatomy
39a, Gorky street, Chita, 672000
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Review
For citations:
Mikhailichenko M.I., Shapovalov K.G., Mudrov V.A., Grusdeva O.S. The role of matrix metalloproteinases and their inhibitors in patients with local cold injury. Yakut Medical Journal. 2020;(2):72-76. https://doi.org/10.25789/YMJ.2020.70.22
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