Relationship of cognitive disorders with clinical features of alcohol dependence
https://doi.org/10.25789/YMJ.2020.70.19
Abstract
The study was conducted in a group of patients with alcohol dependence after detoxification to identify the relationship between indicators of cognitive functioning and clinical features of the formation and course of alcohol dependence.
It was found that alcohol dependence causes a heterogeneous change in the level of cognitive functioning: violation of inhibitory control, decrease in the volume of spatial working memory, attention and cognitive flexibility. Statistically significant correlations were found between clinical data and the degree of cognitive impairment.
Thus, the earlier age of the first sample of alcohol significantly affects the reduction of brake control, which increases the risk of forming alcohol dependence at a young age. The age of alcohol dependence and the associated number of hospitalizations leads to impaired cognitive functioning in the form of reduced spatial working memory and cognitive flexibility. The severity of alcohol dependence primarily determines the degree of cognitive flexibility decline.
Supporting agencies: The study was carried out with the financial support of the Tomsk region Administration and RFBR 19-413-703007.
About the Authors
S. A. Galkin
Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
Galkin Stanislav A. – PhD Student
4, Aleutskaya Str., Tomsk, 634014
A. G. Peshkovskaya
Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
Peshkovskaya Anastasia G. – Researcher
4, Aleutskaya Str., Tomsk, 634014
O. V. Roshchina
Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
Roshchina Olga V. – Researcher
4, Aleutskaya Str., Tomsk, 634014
N. I. Kisel
Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
Kisel Nataliya I. – PhD
4, Aleutskaya Str., Tomsk, 634014
S. A. Ivanova
Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ivanova Svetlana A. – DM, Professor, Head of the Laboratory of Molecular Genetics and Biochemistry, Deputy Director for Science
4, Aleutskaya Str., Tomsk, 634014
N. A. Bokhan
Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences;
Siberian State Medical University of Russia
Russian Federation
Russian Federation
Bokhan Nikolay A. – DM, Professor, Аcademician of the Russian Academy of Sciences academician, RAS, Director
4, Aleutskaya Str., Tomsk, 634014;
head of the Department of psychiatry, psychotherapy, narcology with the course med. the psychology
2, Moscow Trakt, Tomsk, 634050
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Review
For citations:
Galkin S.A., Peshkovskaya A.G., Roshchina O.V., Kisel N.I., Ivanova S.A., Bokhan N.A. Relationship of cognitive disorders with clinical features of alcohol dependence. Yakut Medical Journal. 2020;(2):62-65. https://doi.org/10.25789/YMJ.2020.70.19
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