Activity of prooxidant and antioxidant systems enzymes in plasma of rheumatoid arthritis patients
https://doi.org/10.25789/YMJ.2020.70.08
Abstract
We conducted research of the plasma enzymatic activities in RA patients with different clinical manifestations. The dependence of XO, XDG, SOD activities on RA activity and presence of extra-articular manifestations was analyzed. We have revealed substantial changes in all the plasma enzymatic activities of RA patients. These changes were multidirectional. XO and SOD activities were increased in all RA patients. XO activity have been reached its highest values at maximum disease activity and presence extra-articular involvements, SOD activity – in moderate and high disease activities as well as in patients with articular form of RA. XDG activity was increased at low disease activity and articular form of RA, while moderate, high disease activities and extra-articular involvements were characterized by decreased activity of this enzyme. Plasma enzymatic profile in RA patients is characterized by an increase of an increase in the intensity of oxidative and antioxidant processes.
About the Authors
S. A. Bedina
Research Institute for Clinical and Experimental Rheumatology named after A.B. Zborovsky
Russian Federation
Russian Federation
Svetlana Aleksandrovna Bedina – PhD, senior researcher
76, Zemlyachki str., Volgograd, 400138,tel. (8442) 78-90-95
A. S. Trofimenko
Research Institute for Clinical and Experimental Rheumatology named after A.B. Zborovsky;
Volgograd State Medical University
Russian Federation
Russian Federation
Andrey Stepanovich Trofimenko – PhD,head of department
76, Zemlyachki str., Volgograd, 400138;
Assistant
1, Pavshikh Bortsov Sq., Volgograd, 400131, tel. (8442) 78-90-95
E. E. Mozgovaya
Research Institute for Clinical and Experimental Rheumatology named after A.B. Zborovsky
Russian Federation
Russian Federation
Elena Eduardovna Mozgovaya – PhD, leading researcher
76, Zemlyachki str., Volgograd, 400138,tel. (8442) 78-90-95
S. S. Spitsyna
Research Institute for Clinical and Experimental Rheumatology named after A.B. Zborovsky;
Volgograd State Medical University
Russian Federation
Russian Federation
Svetlana Sergeyevna Spitsyna – junior researcher
76, Zemlyachki str., Volgograd, 400138;
Assistant
1, Pavshikh Bortsov Sq., Volgograd, 400131,tel. (8442) 78-90- 95
M. A. Mamus
Research Institute for Clinical and Experimental Rheumatology named after A.B. Zborovsky
Russian Federation
Russian Federation
Mariya Anatolyevna Mamus – junior researcher
76, Zemlyachki str., Volgograd, 400138, tel. (8442) 78-90-95
E. A. Tikhomirova
Research Institute for Clinical and Experimental Rheumatology named after A.B. Zborovsky
Russian Federation
Russian Federation
Ekaterina Andreyevna Tikhomirova – junior researcher
76, Zemlyachki str., Volgograd, 400138, tel. (8442) 78-90-95
References
1. Neutrophil extracellular traps and their eventual role in the anti-citrullinated protein antibodies generation in rheumatoid arthritis / M.A. Mamus [et al.] // Actual problems of modern rheumatology: Collected papers / Zborovskaya I.A., ed. – М.: Planet, 2018. – V. XXXV. – P. 202-211. DOI: 10.18411/978-5-907109-24-7-2018-xxxv-202-211
2. Vorobjeva N.V. Neutrophil extracellular traps: mechanisms of formation and role in health and disease / N.V. Vorobjeva, B.V. Pinegin // Biochemistry. – 2014. – V. 79. - №. 12. – P. 1580–1591.
3. Dubinina E.E. Activity and isozyme spectrum of superoxide dismutase human erythrocytis and blood plasma / E.E. Dubinina, L.A. Salnikova, L.F. Efimova // Lab. Business. – 1983. – № 10. – P. 30-33.
4. Martemyanov V.F. Clinical significance of research of the activity of enzymes and isozymes of purine metabolism in the blood plasma of patients with ankylosing spondylitis / V.F. Martemyanov, E.E. Mozgovaya, S.A. Bedina // International journal of applied and fundamental research. – 2015. – V. 12. - № 6. – P. 1048-1052.
5. Nadeev A.D. Reactive oxygen species in the cells of cardiovascular system / A.D. Nadeev, N.V. Goncharov // Complex Issues of Cardiovascular Diseases. – 2014. – № 4. – P. 80-94. DOI: 10.17802/2306-1278-2014-4-80-94
6. Russian Clinical recommendations. Rheumatology / Nasonov E.L., ed. M.: GJeOTARMedia, 2017. – 464 p.
7. 2010 Rheumatoid arthritis classification criteria. An American College of Rheumatology/ European League Against Rheumatism collaborative initiative / D. Aletaha [et al.] // Arthritis Rheum. – 2010. – V. 62. – P. 2569–2581. DOI: 10.1136/ard.2010.130310.
8. Angelotti F. One year in review 2017: pathogenesis of rheumatoid arthritis / F. Angelotti [et al.] // Clin.Exp.Rheumatol. – 2017. – V. 35(3). – P. 368-378.
9. Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility / C. Sur Chowdhury [et al.] // Arthritis Res Ther. – 2014. – V. 16. – P. R122. – (https://arthritis-research.biomedcentral.com/articles/10.1186/ar4579). DOI: 10.1186/ar4579
10. Ma V.Y. Incidence, prevalence, costs, and impact on disability of common conditions requiring rehabilitation in the United States: stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, osteoarthritis, rheumatoid arthritis, limb loss, and back pain / V.Y. Ma, L. Chan, K.J.Carruthers // Arch Phys Med Rehabil. – 2014. – V. 95(5). – P. 986-995. DOI: 10.1016/j.apmr.2013.10.032
11. Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis / A.I. Catrina [et al.] // Nat Rev Immunol. – 2017. – V. 13(2). – P. 79-86. DOI: 10.1038/nrrheum.2016.200.
12. NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis / R. Khandpur [et al.] // Sci Transl Med. – 2013. – V. 5(178). – P.178ra40. – (https://stm.sciencemag.org/content/5/178/178ra40). DOI: 10.1126/scitranslmed.3005580
13. Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs / E. Corsiero [et al.] // Ann Rheum Dis. – 2016. – V. 75. – P. 1866-1875. DOI: 10.1136/annrheumdis-2015-208356.
14. The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans / W. Stoiber [et al.] // Biomolecules. – 2015. – V. 5. – P. 702-723. DOI: 10.3390/biom5020702.
15. Wright H.L. The multifactorial role of neutrophils in rheumatoid arthritis / H.L. Wright, R.J. Moots, S.W. Edwards // Nature Reviews Rheumatology. – 2014. – V. 10(10). – P. 593-601. – (http://www.nature.com/nrrheum/journal/vaop/ncurrent/full/nrrheum.2014.80.html). DOI: 10.1038/nrrheum.2014.80.
Review
For citations:
Bedina S.A., Trofimenko A.S., Mozgovaya E.E., Spitsyna S.S., Mamus M.A., Tikhomirova E.A. Activity of prooxidant and antioxidant systems enzymes in plasma of rheumatoid arthritis patients. Yakut Medical Journal. 2020;(2):28-30. https://doi.org/10.25789/YMJ.2020.70.08
Views:
17
Email this article 