Apathy as a non-motor symptom of Parkinson’s disease and Huntington’s chorea
https://doi.org/10.25789/YMJ.2020.70.07
Abstract
The article presents the results of a study of the frequency and clinical profile of apathy in patients with Parkinson's disease and Huntington's disease. A similar frequency of apathy was found in these two neurodegenerative diseases, but with different clinical correlations, due to the involvement of different brain regions in the pathological process. Thus, in patients with Parkinson's disease, a positive correlation was found between apathy and severe depression, anxiety and drowsiness, while in patients with Huntington's disease – with the duration of the disease and cognitive disorders. Thus apathy as a non-motor symptom of the two neurodegenerative disorders has a similar prevalence, but different clinical profile: in Parkinson's disease, it is mainly associated with emotional and affective disorders («emotional apathy»), while in Huntington's disease – with cognitive disorders («cognitive apathy»).
Keywords
apathy,
Huntington disease,
Parkinson disease,
cognitive disorders,
depression,
psychopathological symptoms,
non-motor symptoms
Supporting agencies: The research was supported by the Grant Council of the President of the Russian Federation (grant № MK813.2019.7, "Clinical and epidemiological features of neurodegenerative diseases of the Tomsk region").
About the Authors
M. A. Nikitina
Siberian State Medical University
Russian Federation
Russian Federation
Nikitina Maria A. – MD, PhD, Associate Professor, Department of Neurology and Neurosurgery
Tomsk, 8-913-865-4918
N. G. Brazovskaya
Siberian State Medical University
Russian Federation
Russian Federation
Brazovskaya Natalia G. – PhD, Associate Professor, Department of Medical and Biological Cybernetics
Tomsk
8-913-884-7333
N. G. Zhukova
Siberian State Medical University
Russian Federation
Russian Federation
Zhukova Natalya G. – MD, PhD, Professor, Department of Neurology and Neurosurgery
Tomsk
8-913-824-6202
V. M. Alifirova
Siberian State Medical University
Russian Federation
Russian Federation
Alifirova Valentina M. – MD, PhD, Professor, Head of the Department of Neurology and Neurosurgery
Tomsk
8-913-850-0240
E. Yu. Bragina
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
Bragina Elena Yu. – PhD, Senior Researcher, Laboratory of Population Genetics
Tomsk
8-913- 823-4122
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Review
For citations:
Nikitina M.A., Brazovskaya N.G., Zhukova N.G., Alifirova V.M., Bragina E.Yu. Apathy as a non-motor symptom of Parkinson’s disease and Huntington’s chorea. Yakut Medical Journal. 2020;(2):24-27. https://doi.org/10.25789/YMJ.2020.70.07
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