Migration activity of immunocompetent cells in various pathologies of the gastrointestinal tract
https://doi.org/10.25789/YMJ.2020.70.01
Abstract
This study focuses on the migration and functional activity of immunocompetent cells in the intestinal contents in people with various pathologies of the gastrointestinal tract and in practically healthy people. Actively phagocytic neutrophilic granulocytes and monocytes, as well as lymphocytes without signs of degeneration and plasma cells, were recorded in the intestinal contents. Differences in the migration activity of cells depended on the pathology of the gastrointestinal tract. The levels of immunocompetent cells in the contents of the intestine in practically healthy people were determined. In gastrointestinal diseases, abnormal concentrations of pro-inflammatory cytokines are detected at a high frequency, the highest content of these cytokines have been recorded in malignant intestinal neoplasms.
Supporting agencies: This work was carried out as part of a fundamental research program on the topic of the laboratory of environmental immunology by the FCIARctic project № АААА-А17-117033010124-7.
About the Authors
V. A. Shtaborov
N. Laverov Federal Center for Integrated Arctic Research, Arkhangelsk, Russian Federation
Russian Federation
Russian Federation
Shtaborov Vyacheslav Anatol'evich – PhD (Biology), Senior Researcher
L. K. Dobrodeeva
N. Laverov Federal Center for Integrated Arctic Research, Arkhangelsk, Russian Federation
Russian Federation
Russian Federation
Dobrodeeva Liliya Konstantinovna – MD, prof., Director, Chief Researcher
V. P. Patrakeeva
N. Laverov Federal Center for Integrated Arctic Research, Arkhangelsk, Russian Federation
Russian Federation
Russian Federation
Patrakeeva Veronika Pavlovna – PhD (Biology), Head of lab., Leading Researcher
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Review
For citations:
Shtaborov V.A., Dobrodeeva L.K., Patrakeeva V.P. Migration activity of immunocompetent cells in various pathologies of the gastrointestinal tract. Yakut Medical Journal. 2020;(2):6-9. https://doi.org/10.25789/YMJ.2020.70.01
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