Обонятельная дисфункция как ключевой симптом COVID-19: обзор, основанный на современных исследованиях Чухнина Е.Г., Полина М.Л., Дуглас Н.И.
https://doi.org/10.25789/YMJ.2021.74.27
Аннотация
В статье рассмотрены данные, основанные на современной литературе об обонятельной дисфункции у пациентов с COVID-19. Многочисленные исследования показали, что частота встречаемости обонятельной дисфункции у пациентов с COVID-19 составляет от 33,9 до 68 %, причем у женщин намного выше. У пациентов с COVID-19 может наблюдаться внезапная обонятельная дисфункция без каких-либо других симптомов. Отоларингологи должны обращать внимание на симптом аносмии в амбулаторных условиях, чтобы как можно быстрее диагностировать COVID-19. Многие вопросы, которые так или иначе связаны с потерей обоняния при коронавирусной инфекции, остаются на сегодняшний день нерешенными.
Об авторах
И. А. СинякинРоссия
Синякин Иван Алексеевич – студент
г. Благовещенск
А. А. Панова
Россия
Панова Алина Александровна – студент
г. Благовещенск
Т. А. Баталова
Россия
Баталова Татьяна Анатольевна – доцент, д.б.н., зав. кафедрой
г. Благовещенск
Список литературы
1. Блоцкий А.А. Хронические воспалительные заболевания гайморовых пазух в условиях Амурской области: Монография / А.А. Блоцкий, С.С. Целуйко. – Благовещенск, 2015. - С.25.
2. Войцеховский В.В. Случай болезни рендю-ослера с поражением полости носа и бронхов / В.В. Войцеховский, Н.Д. Гоборов, С.И. Ткачева, Е.А. Филатова // Бюллетень физиологии и патологии дыхания. 2017;(63):91-97. https://doi.org/10.12737/article_58e45dce7e75d0.73462907
3. Akerlund A., Bende M., Murphy C. Olfactory threshold and nasal mucosal changes in experimentally induced common cold. Acta Otolaryngol. 1995;115:88–92. doi: 10.3109/00016489509133353.
4. Baig A.M., Khaleeq A., Ali U., Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Nerosci. 2020;11:995–998. doi: 10.1021/acschemneuro.0c00122.
5. .Baig A.M. Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neurosci Ther. 2020;26:499–501. doi: 10.1111//cns.13372.
6. Bagheri SH, Asghari A, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, Jalessi M, Mohebbi A, Alizadeh R, Honarmand AA, Ghalehbaghi B, Salimi A, Dehghani Firouzabadi F. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran. Med J Islam Repub Iran. 2020 (15 Jun);34:62. doi: 10.1101/2020.03.23.20041889.
7. Beltrán-Corbellini, Á., Chico-García, J.L., Martínez-Poles, J., Rodríguez-Jorge, F., Natera-Villalba, E., Gómez-Corral, J., Gómez-López, A., Monreal, E., Parra-Díaz, P., Cortés-Cuevas, J.L., Galán, J.C., Fragola-Arnau, C., Porta-Etessam, J., Masjuan, J. and Alonso-Cánovas, A. (2020), Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case–control study. Eur J Neurol, 27: 1738-1741. https://doi.org/10.1111/ene.14273
8. Colavita F, Lapa D, Carletti F, Lalle E, Bordi L, Marsella P, Nicastri E, Bevilacqua N, Giancola ML, Corpolongo A, Ippolito G, Capobianchi MR, Castilletti C. SARS-CoV-2 Isolation From Ocular Secretions of a Patient With COVID-19 in Italy With Prolonged Viral RNA Detection. Ann Intern Med. 2020 Aug 4;173(3):242-243. doi: 10.7326/M20-1176. Epub 2020 Apr 17. PMID: 32302380; PMCID: PMC7175424.
9. Eliezer M, Hautefort C, Hamel AL, Verillaud B, Herman P, Houdart E, Eloit C. Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19. JAMA Otolaryngol Head Neck Surg. 2020 Jul 1;146(7):674-675. doi: 10.1001/jamaoto.2020.0832. PMID: 32267483
10. Forster P., Forster L., Renfrew C., Forster M. Phylogenetic network analysis of SARS-CoV-2 genomes. Proc Natl Acad Sci U S A. 2020;117:9241–9243. doi: 10.1073/pnas.2004999117.
11. Gengler I., Wang J.C., Speth M.M., Sedaghat A.R. Laryngoscope investigative otolaryngology. April 10, 2020. Sinonasal pathophysiology of SARS-CoV-2 and COVID-19: a systematic review of the current evidence.
12. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, Rusconi S, Gervasoni C, Ridolfo AL, Rizzardini G, Antinori S, Galli M. Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study. Clin Infect Dis. 2020 Jul 28;71(15):889-890. doi: 10.1093/cid/ciaa330. PMID: 32215618; PMCID: PMC7184514.
13. Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–1720. doi: 10.1056/NEJMoa2002032.
14. Heidari F., Karimi E., Firouzifar M., Khamushian P., Ansari R., Mohammadi Ardehali M. Anosmia as a prominent symptom of COVID-19 infection. Rhinology. 2020;58:302–303. doi: 10.4193/Rhin20.140.
15. Hummel T., Whitcroft K.L., Andrews P., Altundag A., Cinghi C., Costanzo R.M. Position paper on olfactory dysfunction. Rhinol Suppl. 2017;54:1–30.
16. Hwang C.S. Olfactory neuropathy in severe acute respiratory syndrome: report of a case. Acta Neurol Taiwan. 2006;15:26–28.
17. Jan C Luers, Alexander C Rokohl, Niklas Loreck, Philomena A Wawer Matos, Max Augustin, Felix Dewald, Florian Klein, Clara Lehmann, Ludwig M Heindl, Olfactory and Gustatory Dysfunction in Coronavirus Disease 2019 (COVID-19), Clinical Infectious Diseases, Volume 71, Issue 16, 15 Oct.2020, P. 2262–2264, https://doi.org/10.1093/cid/ciaa525
18. Jafek B.W., Murrow B., Michaels R., Restrepo D., Linschoten M. Biopsies of human olfactory epithelium. Chem Senses. 2002;27:623–628. doi: 10.1093/chemse/27.7.623.
19. Klopfenstein T., Kadiane-Oussou N.J., Toko L., Royer P.Y., Lepiller Q., Gendrin V. Features of anosmia in COVID-19. Med Mal Infect. 2020 doi: 10.1016/j.medmal.2020.04.006. Volume 50, Issue 5, Aug.2020; P. 436-439
20. Koyuncu O.O., Hogue I.B., Enquist L.W. Virus infections in the nervous system. Cell Host Microbe. 2013;13:379–393. doi: 10.1016//j.chom.2013.03.010.
21. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261. doi: 10.1007/s00405-020-05965-1. Epub 2020 Apr 6. PMID: 32253535; PMCID: PMC7134551.
22. Li Q., Guan X., Wu P., Wang X., Zhou L., Tong Y. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382:1199–1207. doi: 10.1056/NEJMoa2001316.
23. Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, Sun L, Duan Y, Cai J, Westerdahl D, Liu X, Xu K, Ho KF, Kan H, Fu Q, Lan K. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. 2020 Jun;582(7813):557-560. doi: 10.1038/s41586-020-2271-3. Epub 2020 Apr 27. PMID: 32340022.
24. Lovato A, de Filippis C, Marioni G. Upper airway symptoms in coronavirus disease 2019 (COVID-19). Am J Otolaryngol. 2020 May-Jun;41(3):102474. doi: 10.1016/j.amjoto.2020.102474. Epub 2020 Apr 4. PMID: 32278470; PMCID: PMC7128936.
25. Lovato A, de Filippis C. Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Ear Nose Throat J. 2020 Nov;99(9):569-576. doi: 10.1177/0145561320920762. Epub 2020 Apr 13. PMID: 32283980.
26. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288; PMCID: PMC7149362.
27. Meng X, Dai Z, Hang C, Wang Y. Smartphone-enabled wireless otoscope-assisted online telemedicine during the COVID-19 outbreak. Am J Otolaryngol. 2020 May-Jun;41(3):102476. doi: 10.1016/j.amjoto.2020.102476. Epub 2020 Apr 4. PMID: 32305252; PMCID: PMC7128762.
28. Menni, C., Valdes, A.M., Freidin, M.B. et al. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med 26, 1037–1040 (2020). https://doi.org/10.1038/s41591-020-0916-2
29. Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950. doi: 10.1002/alr.22587. Epub 2020 Jun 18. PMID: 32301284; PMCID: PMC7262123.
30. Ottaviano G, Carecchio M, Scarpa B, Marchese-Ragona R. Olfactory and rhinological evaluations in SARS-CoV-2 patients complaining of olfactory loss. Rhinology. 2020 Aug 1;58(4):400-401. doi: 10.4193/Rhin20.136. PMID: 32338254.
31. Rockx B., Kuiken T., Herfst S., Bestebroer T., Lamers M.M., Oude Munnink B.B. Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model. Science. 2020;368:1012–1015. doi: 10.1126/science.abb7314.
32. Ruthberg JS, Quereshy HA, Jella TK, Kocharyan A, D'Anza B, Maronian N, Otteson TD. Geospatial analysis of COVID-19 and otolaryngologists above age 60. Am J Otolaryngol. 2020 Jul-Aug;41(4):102514. doi: 10.1016/j.amjoto.2020.102514. Epub 2020 Apr 30. PMID: 32386898; PMCID: PMC7192070.
33. Soler ZM, Patel ZM, Turner JH, Holbrook EH. A primer on viral-associated olfactory loss in the era of COVID-19. Int Forum Allergy Rhinol. 2020 Jul;10(7):814-820. doi: 10.1002/alr.22578. Epub 2020 Jun 1. PMID: 32271490; PMCID: PMC7262311.
34. Spinato G., Fabbris C., Polesel J., Cazzador D., Borsetto D., Hopkins C. Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection. Jama. 2020;323:2089–2090. doi: 10.1001/jama.2020.6771.
35. Sungnak W., Huang N., Bécavin C., Berg M., Queen R., Litvinukova M. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26:681–687. doi: 10.1038/s41591-020-0868-6.
36. Vaira LA, Salzano G, Petrocelli M, Deiana G, Salzano FA, De Riu G. Validation of a self-administered olfactory and gustatory test for the remotely evaluation of COVID-19 patients in home quarantine. Head Neck. 2020 Jul;42(7):1570-1576. doi: 10.1002/hed.26228. Epub 2020 May 9. PMID: 32357379; PMCID: PMC7267597.
37. Wagner T, Shweta F, Murugadoss K, Awasthi S, Venkatakrishnan AJ, Bade S, Puranik A, Kang M, Pickering BW, O'Horo JC, Bauer PR, Razonable RR, Vergidis P, Temesgen Z, Rizza S, Mahmood M, Wilson WR, Challener D, Anand P, Liebers M, Doctor Z, Silvert E, Solomon H, Anand A, Barve R, Gores G, Williams AW, Morice WG 2nd, Halamka J, Badley A, Soundararajan V. Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis. Elife. 2020 Jul 7;9:e58227. doi: 10.7554/eLife.58227. PMID: 32633720; PMCID: PMC7410498.
38. Williams F.M., Freydin M., Mangino M., Couvreur S., Visconti A., Bowyer R.C. Self-reported symptoms of covid-19 including symptoms most predictive of SARSCoV-2 infection, are heritable. medRxiv. 2020 doi: 10.1101/2020.04.22.20072124. [2020.2004.2022.20072124, April 27]
39. World Health Organization Coronavirus disease 2019 (COVID-19) situation report-104. https://www.who.int/publications/m/item/weekly-epidemiological-update---27-january-2021
40. World Health Organization WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-generals-remarks-at-the-media-briefing-on-2019-ncovon-11-februarv-2020
41. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, Liu C, Yang C. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020 Jul;87:18-22. doi: 10.1016/j.bbi.2020.03.031. Epub 2020 Mar 30. PMID: 32240762; PMCID: PMC7146689.
42. Yan CH, Faraji F, Prajapati DP, Ostrander BT, DeConde AS. Self-reported olfactory loss associates with outpatient clinical course in COVID-19// Int Forum Allergy Rhinol. 2020 Jul;10(7):821-831. doi: 10.1002/alr.22592. Epub 2020 Jun 7. PMID: 32329222; PMCID: PMC7264572.
43. Yao H., Lu X., Chen Q., Xu K., Chen Y., Cheng L. Patient-derived mutations impact pathogenicity of SARS-CoV-2. medRxiv. 2020 doi: 10.1101/2020.04.14.20060160. [2020.2004.2014.20060160, April 27]
44. Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS. Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum AllergyRhinol. 2020 Jul;10(7):806-813. doi: 10.1002/alr.22579. Epub 2020 Jun 1. PMID: 32279441; PMCID: PMC7262089.
45. Yeo C., Kaushal S., Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020;5:335–337. doi: 10.1016/S2468-1253(20)30048-0.
46. Zhao C, Viana A Jr, Wang Y, Wei HQ, Yan AH, Capasso R. Otolaryngology during COVID-19: Preventive care and precautionary measures. Am J Otolaryngol. 2020 Jul-Aug;41(4):102508. doi: 10.1016/j.amjoto.2020.102508. Epub 2020 Apr 22. PMID: 32345446; PMCID: PMC7195080.
47. Zou L., Ruan F., Huang M., Liang L., Huang H., Hong Z. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382:1177–1179. doi: 10.1056/NEJMc2001737.
Рецензия
Для цитирования:
Синякин И.А., Панова А.А., Баталова Т.А. Обонятельная дисфункция как ключевой симптом COVID-19: обзор, основанный на современных исследованиях Чухнина Е.Г., Полина М.Л., Дуглас Н.И. Якутский медицинский журнал. 2021;(2):104-108. https://doi.org/10.25789/YMJ.2021.74.27
For citation:
Sinyakin I.A., Panova A.A., Batalova T.A. Olfactory dysfunction as a key symptom of Covid-19: a review based on the current research. Yakut Medical Journal. 2021;(2):104-108. https://doi.org/10.25789/YMJ.2021.74.27