Contribution of IL12A, IL12B, IL13 and IL12RB2 gene polymorphisms to the development of chronic obstructive pulmonary disease in the ethnic group of tatars

The analysis of the association of polymorphic variants of the genes IL12A (rs568408, rs2243115), IL12B (rs3212227), IL13 (rs20541), IL12RB2 (rs3762317) with the development of chronic obstructive pulmonary disease (COPD) was carried out as well as the influence of allelic variants of the studied candidate loci on the variability of indicators characterizing the progression of airway obstruction, the intensity and experience of smoking. An association of polymorphic variants of genes IL12A (rs568408, rs2243115) and IL13 (rs20541) with the development of COPD, indicators of respiratory function and smoking index was established. The data obtained confirm the assumption about the essential role of genes responsible for the synthesis of α- and β-subunits of IL12, structural α-helices of IL13 in the formation of a predisposition to COPD and the progression of the disease.

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