ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.75.05ymj-531Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHВклад полиморфизмов генов IL12A, IL12B, IL13 И IL12RB2 в развитие хронической обструктивной болезни легких в этнической группе татарContribution of IL12A, IL12B, IL13 and IL12RB2 gene polymorphisms to the development of chronic obstructive pulmonary disease in the ethnic group of tatarshttps://orcid.org/0000-0002-1695-5173КорытинаГ. Ф.KorytinaG. F.

Корытина Гульназ Фаритовна – д.б.н., доцент, гл.н.с.

г. Уфа;

проф.

Korytina Gulnaz Faritovna - corresponding author, Doctor of Biological Sciences, Associate Professor, Chief Researcher, Laboratory of Physiological Genetics

450054, Ufa, Pr. October, 71, tel. (fax): (347) 2356088

GUO VPO. 89174083049

Guly_Kory@mail.ruЗулкарнеевШ. Р.ZulkarneevSh. R.

Зулкарнеев Шамиль Рустэмович – студент 3 курса

Zulkarneev Shamil Rustemovich - 3rd year student of the medical faculty

450000, Ufa, st. Lenin, 3

(347) 2356088

zulkarneev.shamil@gmail.comhttps://orcid.org/0000-0002-1518-774XАзнабаеваЮ. Г.AznabaevaYu. G.

Азнабаева Юлия Геннадиевна – к.м.н., доцент, завуч

Aznabaeva Yulia Gennadievna - Ph.D., associate professor, head teacher of the Department of Propedeutics of Internal Diseases

450000, Ufa, st. Lenin, 3, (347) 2356088

3251251@gmail.comhttps://orcid.org/0000-0002-2944-4428КочетоваО. В.KochetovaO. V.

Кочетова Ольга Владимировна – к.б.н., н.с.

Kochetova Olga V - Ph.D., researcher, Laboratory of Physiological Genetics

450054, Ufa, Pr. October, 71, tel. (Fax): (347) 2356088

olga_mk78@mail.ruХуснутдиноваН. Н.KhusnutdinovaN. N.

Хуснутдинова Наталья Николаевна - к.б.н., н.с.

Khusnutdinova Natalya Nikolaevna - Ph.D., Researcher, Laboratory of Physiological Genetics

450054, Ufa, Pr. October, 71, tel. (Fax): (347) 2356088

ecolab_203@mail.ruАхметкирееваТ. Т.AkhmetkireevaT. T.

Ахметкиреева Тансулпан Тимерхановна – м.н.с.

Akhmetkireeva Tansulpan Timerkhanovna - junior researcher, Laboratory of Physiological Genetics

450054, Ufa, Pr. October, 71, tel. (Fax): (347) 2356088

tansulpan.ufa@gmail.comhttps://orcid.org/0000-0003-2386-6707ЗагидуллинН. Ш.ZagidullinN. Sh.

Загидуллин Науфаль Шамилевич – д.м.н., проф., зав. Кафедрой

Zagidullin Naufal Shamilevich - Doctor of Medical Sciences, Professor, Head of the Department of Propedeutics of Internal Diseases

450000, Ufa, st. Lenin, 3, (347) 2356088

znaufal@mail.ruhttps://orcid.org/0000-0001-8900-2480ВиктороваТ. В.ViktorovaT. V.

Викторова Татьяна Викторовна – д.м.н., проф., зав. Кафедрой

Viktorova Tatyana Viktorovna - Doctor of Medical Sciences, Professor, Head of the Department of Biology

450000, Ufa, st. Lenin, 3, (347) 2356088

t_vict@mail.ruИБГ УФИЦ РАН; Башкирский ГМУРоссияIBG, UFRC RAS; Bashkir State Medical UniversityRussian FederationБашкирский ГМУРоссияBashkir State Medical University, State Educational Institution of Higher Professional EducationRussian FederationИБГ УФИЦ РАНРоссияIBG, UFIC RASRussian FederationИБГ УФИЦ РАНРоссияIBG, UFITS RASRussian Federation202127042025032125Copyright © Корытина Г.Ф., Зулкарнеев Ш.Р., Азнабаева Ю.Г., Кочетова О.В., Хуснутдинова Н.Н., Ахметкиреева Т.Т., Загидуллин Н.Ш., Викторова Т.В., 20252025Корытина Г.Ф., Зулкарнеев Ш.Р., Азнабаева Ю.Г., Кочетова О.В., Хуснутдинова Н.Н., Ахметкиреева Т.Т., Загидуллин Н.Ш., Викторова Т.В.Korytina G.F., Zulkarneev S.R., Aznabaeva Y.G., Kochetova O.V., Khusnutdinova N.N., Akhmetkireeva T.T., Zagidullin N.S., Viktorova T.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/531

Проведен анализ ассоциации полиморфных вариантов генов IL12A (rs568408, rs2243115), IL12B (rs3212227), IL13 (rs20541), IL12RB2 (rs3762317) с развитием хронической обструктивной болезни легких (ХОБЛ), проанализирован вклад аллельных вариантов исследованных локусов генов-кандидатов в вариабельность показателей, характеризующих прогрессирование обструкции дыхательных путей, интенсивность и стаж курения. Установлена ассоциация полиморфных вариантов генов IL12A (rs568408, rs2243115) и IL13 (rs20541) с развитием ХОБЛ, показателями функции внешнего дыхания и индекса курения. Полученные данные подтверждают предположение о существенной роли генов, ответственных за синтез α- и β-субъединиц IL12, структурных α-спиралей IL13 в формировании предрасположенности к ХОБЛ и прогрессировании заболевания.

The analysis of the association of polymorphic variants of the genes IL12A (rs568408, rs2243115), IL12B (rs3212227), IL13 (rs20541), IL12RB2 (rs3762317) with the development of chronic obstructive pulmonary disease (COPD) was carried out as well as the influence of allelic variants of the studied candidate loci on the variability of indicators characterizing the progression of airway obstruction, the intensity and experience of smoking. An association of polymorphic variants of genes IL12A (rs568408, rs2243115) and IL13 (rs20541) with the development of COPD, indicators of respiratory function and smoking index was established. The data obtained confirm the assumption about the essential role of genes responsible for the synthesis of α- and β-subunits of IL12, structural α-helices of IL13 in the formation of a predisposition to COPD and the progression of the disease.

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The authors declare that there are no conflicts of interest present.