The role of leptin genes and leptin receptor genes in the development of child obesity
https://doi.org/10.25789/YMJ.20201.73.26
Abstract
The role of polymorphic variants of leptin (LEP rs2167270) and leptin receptor (LEPR rs1137100) genes in the development of child obesity and eating behavior was estimated. There was no association with the development of obesity when comparing children's groups with each other. At the same time, the association of LEP (rs2167270) was established according to the following scales of the CEBQ questionnaire: “pleasure of eating, EF”, “slowness in eating, SE” and glucose level. For the rs1137100 locus of the LEPR gene, the associations are shown with such anthropometric parameters as birth weight, weight at present, Z-score, and percentile level.
Supporting agencies: This study was partially funded by the Russian Foundation for Basic Research (no. 20-013-00261) and the Ministry of Science and Higher Education of the Russian Federation, Research Work no. АААА-А16-116020350031-4.
About the Authors
O. V. Kochetova
Ufa Federal Research Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Kochetova Olga Vladimirovna - Candidate of Biological Sciences Research Institute of Biochemistry and Genetics
Z. A. Shangareeva
Bashkir State Medical University
Russian Federation
Russian Federation
Shangareeva Zilya Asgatovna - Candidate of Medical Sciences, Associate Professor
T. V. Viktorova
BSMU
Russian Federation
Russian Federation
Viktorova Tatyana Viktorovna - Doctor of Medical Sciences, Prof., Head. Department
G. F. Korytina
FSBSRI UFRC RAS
Russian Federation
Russian Federation
Korytina Gulnaz Faritovna - Doctor of Biological Sciences, Senior Researcher, Head. lab.
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Review
For citations:
Kochetova O.V., Shangareeva Z.A., Viktorova T.V., Korytina G.F. The role of leptin genes and leptin receptor genes in the development of child obesity. Yakut Medical Journal. 2021;(1):97-100. https://doi.org/10.25789/YMJ.20201.73.26
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