Activation of brown adipose tissue in the human body
https://doi.org/10.25789/YMJ.2021.73.24
Abstract
This literature review presents current data on the influence of physiological factors such as cold, nutrition, and starvation, on the activation of brown adi-pose tissue in the adult body. Activation of this tissue stimulates human me-tabolism and may be a potential therapeutic way to fight obesity and related diseases.
About the Authors
A. V. Efremova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Efremova Agrafena Vladimirovna – Candidate of Biological Sciences, Phd, Senior Researcher
V. A. Alekseev
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Alekseev Vladislav Amirovich – junior researcher
L. I. Konstantinova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Konstantinova Lena Ivanovna – research assistant
E. D. Okhlopkova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Okhlopkova Elena Dmitrievna – Candidate of Biological Sciences, Leading Researcher - Head of Laboratory
L. D. Olesova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Olesova Lyubov Dygynovna – Candidate of Biological Sciences, Leading Researcher
E. I. Semenova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
Semenova Evgeniya Ivanovna – Ph.D., Senior Researcher
References
1. Blessing W. Heating and eating: brown adipose tissue thermo- genesis precedes food ingestion as part of the ultradian basic rest-activity cycle in rats / Blessing W, Mohammed M, Ootsuka Y // Physiol Behav. - 2012. 105(4):966–974. https://doi.org/10.1016/j.physbeh.2011.11.009
2. Blondin D.P. Increased adipose tissue oxidative capacity in cold-acclimated humans / Blondin D.P., Labbé S.M., Tingelstad H.C., Noll C., Kunach M., Phoenix S., Guérin B., Turcotte E.E., Carpentier A.C., Rich-ard D., Haman F. // J Clin Endocrinol Metab. - 2014. 99(3):E438–E446. https://doi.org/10. 1210/jc.2013-3901
3. Blondin D.P. Dietary fatty acid metabolism of brown adipose tissue in cold- acclimated men / Blondin D.P., Tingelstad H.C., Noll C., Frisch F., Phoenix S., Guérin B., Turcotte É.E., Richard D., Haman F., Carpentier A.C. // Nat Commun – 2017. 8:14146. https://doi.org/10.1038/ncomms14146
4. Richard D. Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in hu-mans / Blondin D.P., Frisch F., Phoenix S., Guérin B., Turcotte É.E., Haman F., Richard D., Carpentier A.C. // Cell Metab. – 2017. 25(2):438–447. https://doi. org/10.1016/j.cmet.2016.12.005
5. Boström P.A PGC1-α-dependent myokine that drives brown-fat-like de-velopment of white fat and thermogenesis / Boström P., Wu J., Jedrych-owski M.P., Korde A., Ye L., Lo J.C., Rasbach K.A., Boström E.A., Choi J.H., Long J.Z., Kajimura S., Zingaretti M.C., Vind B.F., Tu H., Cinti S., Højlund K., Gygi S.P., Spiegelman B.M. // Nature. – 2012. 481(7382):463–468. https://doi.org/10.1038/nature10777
6. Cannon B. Brown adipose tissue: function and physiological significance / Cannon B., Nedergaard J. // Physical Rev. - 2004; 84: 277-359. https://doi.org/10.1152/physrev.00015.2003
7. / Chondronikola M. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans / Chondronikola M., Volpi E., Børsheim E., Porter C., Annamalai P., Enerbäck S., Lidell M.E., Saraf M.K., Labbe S.M., Hurren N.M., Yfanti C., Chao T., Andersen C.R., Cesani F., Hawkins H., Sidossis L.S. (2014 Diabetes 63(12):4089–4099. https://doi.org/10.2337/db14-0746
8. Cohade C. “USA-Fat”: prevalence is related to ambient outdoor tempera-ture-evaluation with 18F-FDG PET/CT / Cohade C., Mourtzikos K.A., Wahl R.L. // J Nucl Med. – 2003. 44(8):1267–1270
9. Van der Lans A.A. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis // Van der Lans A.A., Hoeks J,, Brans B., Vijgen G.H., Visser M.G., Vosselman M.J., Hansen J., Jörgensen J.A., Wu J., Mottaghy F.M., Schrauwen P., van Marken Lichtenbelt W.D. // J Clin Invest 123. – 2013. (8):3395–3403. https://doi.org/10.1172/JCI68993
10. Hales C.M. Prevalence of Obesity among Adults and Youth: United States / Hales C.M., Carroll M.D., Fryar C.D., Ogden, C.L. // National Center for Health Statistics Website. - 2015–2016, 2017 Available online: https://www.cdc.gov/nchs/products/databriefs/db288.htm (accessed on 7 July 2020).
11. Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance / Hanssen M.J., Wierts R., Hoeks J., Gemmink A., Brans B., Mottaghy F.M., Schrauwen P., van Marken Lichtenbelt W.D. // Diabetologia. – 2015. 58(3):586–595. https://doi.org/10.1007/ s00125-014-3465-8
12. Hany T.F. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region / Hany T.F., Gharehpapagh E., Kamel E.M., Buck A., Himms-Hagen J., von Schulthess G.K. // Eur J Nucl Med Mol Imaging. – 2002. 29(10):1393–1398
13. Himms-Hagen J. Obesity may be due to a malfunctioning of brown fat // Can Med Assoc J. 1979. 121 (10):1361–1364
14. van Marken Lichtenbelt W.D. Cold-activated brown adipose tissue in healthy men / van Marken Lichtenbelt W.D., Vanhommerig J.W., Smulders N.M., Drossaerts J.M., Kemerink G.J., Bouvy N.D., Schrauwen P., Teule G.J. // N Engl J Med . – 2009. 360(15):1500–1508. Erratum in: N Engl J Med. 2009;360(18):1917
15. Muzik O. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat / Muzik O., Mangner T.J., Leonard W.R., Kumar A., Janisse J., Granneman J.G. // J Nucl Med. – 2013. 54(4):523–531. https://doi.org/10.2967/jnumed.112.111336
16. Nuutila P. Glucose-free fatty acid cycle operates in human heart and skele-tal muscle in vivo / Nuutila P., Koivisto V.A., Knuuti J., Ruotsalainen U., Teräs M., Haaparanta M., Bergman J., Solin O., Voipio-Pulkki L.M., We-gelius U et al // J Clin Invest . – 19992. 89(6):767–1774
17. Nuutila P. Gender and insulin sensitivity in the heart and in skeletal mus-cles. Studies using positron emission tomography / Nuutila P., Knuuti M.J., Mäki M., Laine H., Ruotsalainen U., Teräs M., Haaparanta M., Solin O., Yki-Järvinen H. // Diabetes. – 1995. 44(1):31–36
18. Oberkofler H. Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans / Oberkofler H., Dal-linger G., Liu Y.M., Hell E., Krempler F., Patsch W. // J Lipid Res. – 1997. 38(10):2125–2133
19. Orava J. Different metabolic responses of human brown adipose tissue to activation by cold and insulin / Orava J., Nuutila P., Lidell M.E., Oikonen V., Noponen T., Viljanen T., Scheinin M., Taittonen M., Niemi T., Ener-bäck S., Virtanen K.A. // Cell Metab. – 2011. 14(2):272–279. https://doi.org/10.1016/j.cmet.2011.06.012
20. Blunted metabolic responses to cold and insulin stimulation in brown adi-pose tissue of obese humans / Orava J., Nuutila P., Noponen T., Parkkola R., Viljanen T., Enerbäck S., Rissanen A., Pietiläinen K.H., Virtanen K.A. // Obesity (Silver Spring). – 2013. 21(11):2279–2287. https://doi.org/10.1002/oby.20456
21. Brown adipose tissue function is accompanied by cerebral activation in lean but not in obese humans / Orava J., Nummenmaa L., Noponen T., Viljanen T., Parkkola R., Nuutila P., Virtanen K.A. // J Cereb Blood Flow Metab. – 2014. 34(6):1018–1023. https://doi.org/10.1038/jcbfm.2014.50
22. Ouellet V. Brown adipose tissue oxidative metabolism contributes to ener-gy expen- diture during acute cold exposure in humans / Ouellet V., Labbé S.M., Blondin D.P., Phoenix S., Guérin B., Haman F., Turcotte E.E., Richard D., Carpentier A.C. // J Clin Invest. – 2012. 122(2):545–552
23. Parysow O. Low-dose oral propranolol could reduce brown adipose tissue F-18 FDG uptake in patients undergoing PET scans / Parysow O., Mol-lerach A.M., Jager V., Racioppi S., San Roman J., Gerbaudo V.H. // Clin Nucl Med. – 2017. 32(5):351–357
24. Pathak K. Fasting and glucose induced thermogenesis in response to three ambient temperatures: a randomized crossover trial in the metabolic syn-drome / Pathak K., Woodman R.J., James A.P., Soares M.J. // Eur J Clin Nutr. – 2018. https://doi.org/10.1038/s41430-017-0058-x
25. Raiko J. Brown adipose tissue triglyceride content is associated with de-creased insulin sensitivity, independently of age and obesity / Raiko J., Holstila M., Virtanen K.A., Orava J., Saunavaara V., Niemi T., Laine J., Taittonen M., Borra R.J., Nuutila P., Parkkola R. // Diabetes Obes Metab. - 2015. 17 (5):516–519. https://doi.org/10.1111/dom.12433
26. Rothwell N.J. A role for brown adipose tissue in diet-induced thermogen-esis / Rothwell N.J., Stock M.J. // Nature. – 1979. 281(5726):31–35
27. Saito M. High incidence of active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity / Saito M., Okamatsu-Ogura Y., Matsushita M., Watanabe K., Yoneshiro T., Nio-Kobayashi J., Iwanaga T., Miyagawa M., Kameya T., Nakada K., Kawai Y., Tsujisaki M. // Diabetes. – 2009. 58(7):1526–1531
28. Siegel E.G. Importance of preabsorptive insulin release on oral glucose tol-erance: studies in pancreatic islet transplanted rats / Siegel E.G., Trimble E.R., Renold A.E., Berthoud H.R. // Gut. – 1998. 21 (11):1002–1009
29. U Din M. Human brown adipose tissue oxygen consumption after meal is similar to cold activated consumption / U Din M., Raiko J., Saari T., Kudomi N., Parkkola R., Nuutila P., Virtanen K.A. // Diabetologia . – 2015. 58(Suppl 1):S331, 691
30. U Din M. Human brown adipose tissue [(15)O]O2 PET imaging in the presence and absence of cold stimulus / U Din M., Raiko J., Saari T., Kudomi N., Tolvanen T., Oikonen V., Teuho J., Sipilä H.T., Savisto N., Parkkola R., Nuutila P., Virtanen K.A. // Eur J Nucl Med Mol Imaging. – 2016. 43 (10):1878–1886. https://doi.org/10.1007/s00259-016-3364y
31. Vijgen G.H. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects / Vijgen G.H., Bouvy N.D., Teule G.J., Brans B., Hoeks J., Schrauwen P., van Marken Lichtenbelt W.D. // J Clin Endocrinol Metab. – 2012. 97(7):E1229–E1233. https://doi.org/10.1210/jc.2012-1289
32. Virtanen K.A. Functional brown adipose tissue in healthy adults / Virtanen K.A., Lidell M.E., Orava J., Heglind M., Westergren R., Niemi T., Taitto-nen M., Laine J., Savisto N.J., Enerbäck S., Nuutila P. // N Engl J Med. – 2009. 360(15):1518–1525. Erratum in: N Engl J Med. 2009;361(11):1123
33. Vosselman M .J. Brown adipose tissue activity after a high-calorie meal in humans / Vosselman M.J., Brans B., van der Lans A.A., Wierts R., van Baak M.A., Mottaghy F.M., Schrauwen P., van Marken Lichtenbelt W.D. // Am J Clin Nutr . – 2013. 98(1):57–64. https://doi.org/10.3945/ajcn.113.059022
34. Williams G. Method for decreasing uptake of 18F-FDG by hypermetabolic brown adipose tissue on PET / Williams G., Kolodny G.M. // AJR Am J Roentgenol. – 2008. 190(5):1406–1409. https://doi.org/10.2214/AJR.07.3205
35. Yoneshiro T. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men / Yoneshiro .T, Aita S., Matsushita M., Kameya T., Nakada K., Kawai Y., Saito M. // Obesity (Silver Spring). – 2011. 19(1):13–16
36. Yoneshiro T. Recruited brown adipose tissue as an antiobesity agent in humans / Yoneshiro T., Aita S., Matsushita M., Kayahara T., Kameya T., Kawai Y., Iwanaga T., Saito M. // J Clin Invest. – 2015. 123 (8):3404–3408. https://doi.org/10.1172/JCI67803
37. WHO. Obesity Report; World Health Organization Website. Available online: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed on 25 January 2020).
Review
For citations:
Efremova A.V., Alekseev V.A., Konstantinova L.I., Okhlopkova E.D., Olesova L.D., Semenova E.I. Activation of brown adipose tissue in the human body. Yakut Medical Journal. 2021;(1):87-91. https://doi.org/10.25789/YMJ.2021.73.24
Views:
12
Email this article 