Features of the immune and metabolic profile of autonomic dysfunction associated with polymorphism of candidate genes
https://doi.org/10.25789/YMJ.2021.73.15
Abstract
The experience of the immune and neurohumoral profile of oil production workers with autonomic dysfunction syndrome associated with polymorphism of candidate genes was studied. The established imbalance of immune (excess of apoptosis and phagocytosis), nervous (excess of dopamine) and metabolic (overexpression of homocysteine and excess of NO due to its unstable forms) regulation, which is realized against the background of polymorphism of genes of detoxification and metabolic enzymes - MTHFR (rs1801128), SULT128 ) and ApoE (rs429358), characterizes the experience of the immune and metabolomic profile of those working with autonomic dysfunction and the risk of atherosclerosis and hypertension.
About the Authors
O. V. Dolgikh
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Dolgikh Oleg Vladimirovich - Doctor of Medical Sciences, Head of the Department of Immunobiological Diagnostics
614045, Perm, 82 Monastyrskaya street
tel. +7(342)236-39-30
N. V. Zaitseva
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Zaitseva Nina Vladimirovna - Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Scientific Director
614045, Perm, 82 Monastyrskaya street
tel. +7(342)236-39-30
N. A. Nikonoshina
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Nikonoshina Natalya Alekseevna - junior research assistant of Department of Immunobiological Diagnostics
614045, Perm, 82 Monastyrskaya street
tel. +7(342)236-39-30
References
1. Nosov A.E. Structural peculiarities of metabolic syndrome in workers employed at oil extracting enterprise / А.Е. Nosov, E.M. Vlasova, A.S. Baidina, O.Yu. Ustinova // Health Risk Analysis. - 2020; 2. – P. 63 – 71. DOI: 10.21668/health.risk/2020.2.07
2. Malashenkova I.K. ApoE gene polymorphism: the impact of ApoE4 allele on systemic inflammation and its role in the pathogenesis of Alzheimer’s disease. I.K. Malashenkova, S.A. Krynskiy, M.V. Mamoshina, N.A. Didkovskiy // Medical Immunology. - 2018; №20(3). – P. 303 – 312] DOI: 10.15789/1563-0625-2018-3-303-312
3. Shklovskiy V.M. A role of genetic factors and related disorder of the folate cycle in ischemic stroke. V.M. Shklovskiy, I.P. Lukashevich, A.Yu. Remennik, S.M. Gerasimova, G.S. Selishchev, D.I. Malin, V.V. Valyaeva // S. Korsakov Journal of Neurology and Psychiatrics. – 2016. - № 116 (8). P. 30 – 32. DOI: 10.17116/jnevro20161168230-32
4. Karamova L.M. Health status of healthy status of healthy oil and petrochemical workers / L.M. Karamova, G.R. Basharova, E.T. Valeeva, R.R. Galimova, N.V. Vlasova, N.R. Gazizova // Occupational Medicine and Human Ecology. – 2015. №4. P. 270–275
5. Patanella A.K. Correlations between peripheral blood mononuclear cell production of BDNF, TNF-alpha, IL-6, IL-10 and cognitive performances in multiple sclerosis patients / A.K. Patanella, M. Zinno, D. Quaranta, V. Nociti, G. Frisullo, G. Gainotti // J Neurosci Res. - 2010; №88 (5). - 1106 – 1112 DOI: 10.1002/jnr.22276.
6. Duramad P., Holland N.T. Biomarkers of immunotoxicity for environmental and public health research, International Journal of Environmental Research and Public Health. - 2011. - №8(5). - P.1388–1401. DOI: 10.3390/ijerph8051388
7. Levite M. Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases // Acta Physiol. – 2016. - №216(1). –P. 42 – 89. DOI: 10.1111/apha.12476
8. Rommer P.S. Manifestations of neurological symptoms and thromboembolism in adults with MTHFR-deficiency / P.S Rommer, J. Zschocke, B. Fowler, M. Födinger, V. Konstantopoulou, D. Möslinger, E. Stögmann, E. Suess, M. Baumgartner, E. Auff, G. Sunder-Plassmann // J Neurol Sci. - 2017. - №15(383). P.123-127.
9. Mahley R. W. Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism, Arteriosclerosis, thrombosis, and vascular biology. – 2016.- №36(7). – Р.1305 – 1315. DOI: 10.1161/ATVBAHA.116.307023
10. Matt S.M., Gaskill P.J. Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease. J Neuroimmune Pharmacol. – 2020. - №15(1). – Р.114 – 164. doi: 10.1007/s11481-019-09851-4Р
11. Nikonoshina N.A., Dolgikh O.V. The peculiarities of immune regulation and the polymorphic variants of candidate genes associated with them in oil production workers with vegetative regulation disorders. Advances in Health Sciences Research. - 2020; №28. – Р.262 – 265. DOI: 10.2991/ahsr.k.201001.053
12. Sidharthan N.P., Minchin R.F., Butcher N.J. Cytosolic Sulfotransferase 1A3 Is Induced by Dopamine and Protects Neuronal Cells from Dopamine Toxicity: role of D1 receptor - N-methyl-D-aspartate receptor coupling. Journal of Biological Chemistry. – 2013. - №288(48): 34364-34374. DOI: 10.1074/jbc.M113.493239
13. Soluble interleukin-6 receptor in young adults and its relationship with body composition and autonomic nervous system / H.H. León-Ariza, D.A. Botero-Rosas, E.J. Acero-Mondragón, D. Reyes-Cruz // Physiol Rep. - 2019. -№7(24): e14315. DOI: 10.14814/phy2.14315
14. The molecular and cellular effect of homocysteine metabolism imbalance on human health / H. Škovierová, E. Vidomanová, S. Mahmood [et al.] // Int J Mol Sci. – 2016. – №17 (10): e1733. DOI: 10.3390/ijms17101733
Review
For citations:
Dolgikh O.V., Zaitseva N.V., Nikonoshina N.A. Features of the immune and metabolic profile of autonomic dysfunction associated with polymorphism of candidate genes. Yakut Medical Journal. 2021;(1):54-57. https://doi.org/10.25789/YMJ.2021.73.15
Views:
23
Email this article 