ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.73.15ymj-490Research ArticleГИГИЕНА, САНИТАРИЯ, ЭПИДЕМИОЛОГИЯ И МЕДИЦИНСКАЯ ЭКОЛОГИЯHYGIENE, SANITATION, EPIDEMIOLOGY AND MEDICAL ECOLOGYОсобенности иммунного и метаболомного профиля вегетативной дисфункции, сопряженные с полиморфизмом генов-кандидатовFeatures of the immune and metabolic profile of autonomic dysfunction associated with polymorphism of candidate geneshttps://orcid.org/0000-0003-4860-3145ДолгихО. В.DolgikhO. V.

Долгих Олег Владимирович – д.м.н., зав. Отделом

г. Пермь

Dolgikh Oleg Vladimirovich - Doctor of Medical Sciences, Head of the Department of Immunobiological Diagnostics

614045, Perm, 82 Monastyrskaya street

tel. +7(342)236-39-30

oleg@fcrisk.ruhttps://orcid.org/0000-0002-9916-5491ЗайцеваН. В.ZaitsevaN. V.

Зайцева Нина Владимировна – д.м.н., проф., акад. РАН, научный руководитель

г. Пермь

Zaitseva Nina Vladimirovna - Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Scientific Director

614045, Perm, 82 Monastyrskaya street

tel. +7(342)236-39-30

znv@fcrisk.ruhttps://orcid.org/0000-0001-7271-9477НиконошинаН. А.NikonoshinaN. A.

Никоношина Наталья Алексеевна – м.н.с.

г. Пермь

Nikonoshina Natalya Alekseevna - junior research assistant of Department of Immunobiological Diagnostics

614045, Perm, 82 Monastyrskaya street

tel. +7(342)236-39-30

nat08.11@yandex.ruФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения»РоссияFBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"Russian Federation202127042025015457Copyright © Долгих О.В., Зайцева Н.В., Никоношина Н.А., 20252025Долгих О.В., Зайцева Н.В., Никоношина Н.А.Dolgikh O.V., Zaitseva N.V., Nikonoshina N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/490

Изучены стажевые особенности иммунного и нейрогуморального профиля работников предприятия нефтедобычи с синдромом вегетативной дисфункции, сопряженные с полиморфизмом генов-кандидатов.Установленный дисбаланс иммунной (избыточность апоптоза и фагоцитоза), нервной (избыток дофамина) и метаболической (гиперэкспрессия гомоцистеина и избыток NO за счет нестабильных его форм) регуляции, реализующейся на фоне полиморфизма генов ферментов детоксикации и обмена веществ - MTHFR (rs1801133), SULT1A1 (rs9282861) и ApoE (rs429358), характеризует стажевые особенности иммунного и метаболомного профиля работающих с вегетативной дисфункцией и риском формирования атеросклероза и гипертонии.

The experience of the immune and neurohumoral profile of oil production workers with autonomic dysfunction syndrome associated with polymorphism of candidate genes was studied. The established imbalance of immune (excess of apoptosis and phagocytosis), nervous (excess of dopamine) and metabolic (overexpression of homocysteine and excess of NO due to its unstable forms) regulation, which is realized against the background of polymorphism of genes of detoxification and metabolic enzymes - MTHFR (rs1801128), SULT128 ) and ApoE (rs429358), characterizes the experience of the immune and metabolomic profile of those working with autonomic dysfunction and the risk of atherosclerosis and hypertension.

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The authors declare that there are no conflicts of interest present.