Variants of single nucleotide substitutions in the genes of matrix metalloproteinases (MMP-2 and MMP-9) in arterial hypertension in people of working age
https://doi.org/10.25789/YMJ.2021.73.06
Abstract
Point substitutions in genes MMP-2 c.-1306C> T (rs243865) and MMP-9 c.-1562C> T (rs3918242) were studied in people under the age of 60 living in the Primorsky Territory. It was found that differences between the shares of MMP-2 CC, CT, and TT genotypes in the groups of persons with AH and the control group were statistically insignificant (mid-p = 0.16), while for MMP-9 CC, CT, and TT genotypes, these differences were determined (α = 0.05). In the distribution of patients with hypertension, depending on the indicators of relative cardiovascular risk (CVR) in persons with hypertension under 40 in the group with CVR 2, a significant increase in the minor alleles of MMP-9 1562 C/T was found, compared with individuals with CVR 1. The presence of the T allele in MMP-9 gene c.-1562C> T (rs3918242) is associated with a higher risk of cardiovascular diseases in young people with hypertension. Thus, the definition of the abovementioned polymorphism is of particular importance for young patients.
About the Authors
L. V. Rodionova
Federal State Budgetary Educational Institution of Higher Education «Pacific State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Rodionova Larisa Vladimirovna - assistant of Institute of therapy and instrumental diagnostic
Tel.: +7 (423)245-86-05
V. A. Nevzorova
Federal State Budgetary Educational Institution of Higher Education «Pacific State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Nevzorova Vera Afanasyevna director of Institute of therapy and instrumental diagnostic
N. G. Plekhova
Federal State Budgetary Educational Institution of Higher Education «Pacific State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Plekhova Natalia Gennadievna chief of central research laboratory
K. S. Maslennikova
Federal State Budgetary Educational Institution of Higher Education «Pacific State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Maslennikova Kseniya Sergeevna postgraduated student of clinical and laboratory diagnostic department
References
1. Moskalenko M.I. The involvement of polymorphisms of -799 С/T MMP-8 (Rs11225395) and -82 А/G MMP-12 (Rs2276109) of matrix metalloproteinase genes in the formation of essential hypertension in the population of the Central Black Earth Region of Russia / M.I.Moskalenko, V.V.Kapranova, M.I. Chursunov. - 2017; 5 (254):63-67.
2. Prevention of cardiovascular disease 2017. Russian national guidelines // Russian Journal of Cardiology. - 2018; 23(6): 118.
3. Sakovskaya A.V. Polymorphism of genes of matrix metalloproteinases 2 and 9 and indicators of arterial stiffness in individuals with arterial hypertension / A.V.Sakovskaya, V.A. Nevzorova, M.P. Isaeva. Cardiovascular Therapy and Prevention. - 2017; 16 (2): 22–27.
4. Medley T. Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression / T. Medley, T. Cole, A. Dart [et al.]. // Arterioscler Thromb Vasc Biol. - 2004; 24(8):1479-84.
5. Palei A. Tanus-Santos J. Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy / A. Palei, V. Sandrim, L. Amaral [et al.] // Pharmacogenomics journal. 2012 Dec; 12(6):489-98.
6. Ritter A. The rs243866/243865 polymorphisms in MMP-2 gene and the relationship with BP control in obese resistant hypertensive subjects / A. Ritter, A.de Faria, N. Barbaro, A. Sabbatini, N. Corrêa, V. Brunelli, A. Fattori, R. Amorim, R. Modolo, H. Moreno // Gene. 2018; 646:129-135. doi: 10.1016/j.gene.2017.12.023. Epub 2017 Dec 27.
7. Sabbatini A. Matrix metalloproteinase-2 -735C/T polymorphism is associated with resistant hypertension in a specialized outpatient clinic in Brazil / A. Sabbatini, N. Barbaro, A.de Faria, A. Ritter, R. Modolo, N. Correa, V. Brunelli, C. Pinho, V. Fontana, H. Moreno // Gene. 2017 Jul 15; 620: 23-29. doi: 10.1016/j.gene.2017.04.004. Epub 2017 Apr 5.
8. Sierevogel M. Matrix metalloproteinases: a therapeutic target in cardiovascular disease / M. Sierevogel, G. Pasterkamp, D. de Kleijn D [et al.]. // Curr. Pharm. Des.- 2003; 9 (13): 1033-1040.
9. Yang W. Association of Matrix Metalloproteinase-9 Gene -1562C/T Polymorphism with Essential Hypertension: A Systematic Review and MetaAnalysis Article / W. Yang, J. Lu, L.Yang [et al.]. // Iran J. Public Health. 2015; 44(11): 1445-1452.
10. Zhou S. Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension / S. Zhou, J. Feely, J. Spiers [et al.] // J Hum Hypertens. - 2007 Nov; 21(11):861-7.
Review
For citations:
Rodionova L.V., Nevzorova V.A., Plekhova N.G., Maslennikova K.S. Variants of single nucleotide substitutions in the genes of matrix metalloproteinases (MMP-2 and MMP-9) in arterial hypertension in people of working age. Yakut Medical Journal. 2021;(1):21-25. https://doi.org/10.25789/YMJ.2021.73.06
Views:
10
Email this article 