Analysis of associations of PPARGC1A and PPARG genes polymorphisms with metabolic syndrome in persons with vibration disease
https://doi.org/10.25789/YMJ.2021.73.05
Abstract
The aim of this work was to study the relationship between Pro12Ala polymorphisms of the PPARG gene and Gly482Ser of the PPARGC1A gene with metabolic syndrome in individuals with VD. The frequency of alleles and genotypes of these polymorphisms was studied in patients with VD and in the comparison group, and their role in the development of metabolic syndrome (MS) was assessed. It was found that the frequency of MS among individuals with Vibration disease was higher with the same distribution of alleles and genotypes of Pro12Ala polymorphisms of the PPARG gene and Gly482Ser of the PPARGC1A gene in the examined groups. The carriage of the ProPro genotype of the PPARG gene is associated with resistance to MS development in the comparison group. A significant effect of the Pro12Ala polymorphisms of the PPARG gene and Gly482Ser of the PPARGC1A gene on the formation of MS was not revealed in patients with vibration disease.
About the Authors
L. B. Masnavieva
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
665827, Angarsk
I. V. Kudaeva
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
665827, Angarsk
O. A. Dyakovich
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
665827, Angarsk
N. P. Chistova
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
665827, Angarsk
O. V. Naumova
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
665827, Angarsk
References
1. Analysis of gene and molecular markers at patients with various terms of formations of vibratory disease / E.L. Smirnova, E.L. Poteryaeva, V.N. Maksimov [et al.] // Journal of Siberian Medical Sciences. – 2015. – N 6. – P.75 (In Russ.)
2. Belik V.P. The adaptation of methods for isolating DNA from frozen blood. / V.P. Belik, I.V. Kudaeva, L.B. Masnavieva // Medical alphabet. Modern Laboratory. - 2014. – Vol. 1, N 2. – P.36-38. (In Russ.)
3. Ermakova M.A. Interrelation of resistin and adiponectin endothelial dysfunctional markers at arterial hypertension in the context of high professional risk / M.A. Ermakova, L.A. Shpagina // Journal of Siberian Medical Sciences. - 2014; N 2 – P.33. (In Russ.)
4. Detection of hereditary predisposition to development of physical abilities with ‘AmpliSens® Pyroscreen’ reagents kit. / O.P. Dribnokhodova, K.O. Mironov, E.A. Dunaeva, G.A. Shipulin // Medical alphabet. – 2016. – Vol.4: N 23(26). – P.49-54. (In Russ.)
5. Character of homeostasis changes in persons with different genotypes of metabolism regulator genes under extreme conditions. / A.O. Pyatibrat, S.B. Melnov, A.S. Kozlova [et al.] // Bulletin of Russian military medical Academy. – 2015. – N 3(51). – P.103-108. (In Russ.)
6. Panacheva L.A. Prevalence and clinical manifestations of metabolic syndrome in vibration disease / L.A. Panacheva, E.A. Platonova, G.V. Kouznetsova // Russian Journal of Occupational Health and Industrial Ecology. – 2011. – N 10. – P.36-39. (In Russ.)
7. Distribution of serum and erythrocyte genetic markers in the patients with vibration pathology / N.I. Gafarov, V.V. Zakharenkov, T.K. Yadykina, A.S. Kazitskaya // Izvestia of Samara Scientific Center of the Russian Academy of Sciences. – 2014. – Vol.16, N 5. – P.295-298. (In Russ.)
8. Prevalence of metabolic syndrome in different cities of the Russian Federation / Rotar' OP, Libis RA, Isaeva EN. [et al.] // Russian Journal of Cardiology. – 2012. – N 2. – P.55-62. (In Russ.)
9. Siurin S.A. Features of general and occupational pathology in miners of apatite mines in Far North kola research laboratory for occupational health / S.A. Siurin, O.A. Bourakova // Russian Journal of Occupational Health and Industrial Ecology. – 2012. – N 3. – P.15-18. (In Russ.)
10. Syurin S.A. Vibration disease in workers of enterprises in the Russian Arctic / S.A. Syurin // Occupational safety and health. – 2019. – N 3(80). – P.37-41. (In Russ.)
11. Frequency of a metabolic syndrome and its clinical variants in patients with the verified coronary atherosclerosis in Yakutia / A.N. Romanova, A.S. Golderova, M..I Voevoda, E.A. Alekseeva // Yakut Medical Journal. – 2011.– N 2 (34). – P.16-19. (In Russ.)
12. Chernobrivczev P.A. The peculiarities of distribution of genotypes and alleys rs1801282 PPARG in patients with metabolic syndrome in the Donetsk region / P.A. Chernobrivczev, S.V. Pishchulina, M.S. Kishenya // University Clinic. – 201. – Vol. 1, N 3(27). – P.56-60 (In Russ.)
13. Yamshchikova A.V. Co-morbid conditions in the vibration disease patients / A.V. Yamshchikova, A.N. Fleishman, M.O. Gidayatova // Hygiene and Sanitation. – 2019. – Vol. 98, N 7. – P.718-722. (In Russ.). DOI: 10.18821/0016-9900-2019-98 N 7-718-722
14. Association of the variants in the PPARG gene and serum lipid levels: a meta-analysis of 74 studies / Li Q., R. Chen, L. Bie [et al.] // J. Cell. Mol. Med. – 2015. – Vol. 19, N 1. – P. 198-209 DOI: 10.1111/jcmm.12417.
15. Endothelial hemostatic predictors of cardiovascular risk in patients with vibration disease in combination with the arterial hypertension / L.A. Shpagina, O.N. Gerasimenko, V.A. Drobyshev [et al.] // Journal of Siberian Medical Sciences. – 2017. – N 1. – P. 3-6.
16. Finck B.N. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease / B.N. Finck, D.P. Kelly // J Clin Invest. – 2006. – N 116(3). – P.615-22. DOI: 10.1172/JCI27794
17. Finck B.N. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease / B.N. Finck, D.P. Kelly // Circulation. – 2007. – Vol. 15; N 115(19). – P.2540-8. DOI: 10.1161/CIRCULATIONAHA.107.670588
18. Kravchenko N.A. Role of PPARS and their isoforms in metabolic disorders related to insulin resistance and diabetes / N.A. Kravchenko, N.V. Yarmysh // Cytology and Genetics. – 2011. – N 45(3). – P.191-199. DOI: 10.3103/S0095452711030042.
19. Metabolic syndrome prevalence in Russia: Preliminary results of a cross-sectional population study / M. Mamedov, N. Suslonova, I. Lisenkova [et al.] // Diabet. Vasc. Dis. Res. – 2007. – N 4(1). – P. 46–47.
20. The Gly482Ser polymorphism in the peroxisome proliferator-activated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men / N. Cheurfa, A.F. Reis, D. Dubois-Laforgue [et al.] // Diabetologia. – 2004. – N 47(11). – P.1980-3. DOI: 10.1007/s00125-004-1567-4
21. The polygenic profile of Russian football players / E.S. Egorova, A.V. Borisova, L.J. Mustafina [et al.] // J Sports Sci. – 2014. – N 32(13). – P.1286-93. doi: 10.1080/02640414.2014.898853.
22. The PPARγ Pro12Ala variant is associated with insulin sensitivity in Russiannormoglycaemic and type 2 diabetic subjects / D.A. Chistiakov, V.A. Potapov, D.S. Khodirev [et al.] // Diabetes & Vascular Disease Research. – 2010. – N 7(1). – P.56–62. DOI: 10.1177/1479164109347689
Review
For citations:
Masnavieva L.B., Kudaeva I.V., Dyakovich O.A., Chistova N.P., Naumova O.V. Analysis of associations of PPARGC1A and PPARG genes polymorphisms with metabolic syndrome in persons with vibration disease. Yakut Medical Journal. 2021;(1):18-21. https://doi.org/10.25789/YMJ.2021.73.05
Views:
15
Email this article 