Maturation of monocytes into dendritic cells by morphological signs in breast cancer
https://doi.org/10.25789/YMJ.2023.83.04
Abstract
Taking into account the complex maturation process of dendritic cells under culturing conditions, as well as the available data of morphological characteristics at various pathological conditions, we find it interesting to assess the features of cell morphology in oncological patients. The purpose of this study was to assess the morphological characteristics of the processes of maturation of dendritic cells in breast cancer. In cancer patients, the potential for cellular viability and maturation compared to healthy individuals is reduced in the early days of cultivation, probably due to the cytotoxicity of chemotherapy and radiation therapy at the time of the study. Cell analysis in the last days of cultivation indicates that the processes of activation of monocyte maturation in dendritic cells in in vitro were significantly higher in oncobols than in healthy individuals.
About the Authors
I. E. Nikolaeva
Medical Institute, M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
NIKOLAEVA Irina Eduardovna – research associate
A. S. Golderova
Medical Institute, M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
GOLDEROVA Aitalina Semyonovna – MD, research associate, Professor
V. G. Ivanova
Medical Institute, M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
VANOVA Violetta Grigoryevna – 6th year student
M. P. Kirillina
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
KIRILLINA Maria Petrovna – PhD in Biology, research scientist, head of the lab.
T. I. Nikolaeva
Medical Institute, M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
NIKOLAEVA Tatiana Ivanovna – PhD, Associate Professor, chief physician of the Yakut Republican oncological dispensary
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Review
For citations:
Nikolaeva I.E., Golderova A.S., Ivanova V.G., Kirillina M.P., Nikolaeva T.I. Maturation of monocytes into dendritic cells by morphological signs in breast cancer. Yakut Medical Journal. 2023;(3):18-21. https://doi.org/10.25789/YMJ.2023.83.04
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