Биологические маркеры в прогнозировании течения спинальной мышечной атрофии и их значение в организации оказания медицинской помощи

Проведен поиск различий между уровнями биомаркеров крови и клиническими проявлениями спинальной мышечной атрофии (СМА) у больных Самарской области в целях получения данных для разработки эффективного метода прогнозирования течения заболевания.

Изучение различий в уровнях креатинина, креатинфосфокиназы и лактатдегидрогеназы среди групп пациентов и их связи с моторными нарушениями не показали статистической значимости. Различия уровней креатинфосфокиназы между группами могут быть связаны с возрастом, массой, полом и уровнями физической активности пациентов. Результаты данной работы говорят о неэффективности оценки уровней креатинина, креатинфосфокиназы и лактатдегидрогеназы в целях мониторинга и прогнозирования течения СМА, а также о нецелесообразности повторного проведения данных лабораторных исследований пациентам со СМА 5q.

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