The level of endogenous intoxication in overweight individuals
https://doi.org/10.25789/YMJ.2023.83.28
Abstract
According to the data obtained, there is an increase in the levels of low and medium molecular weight substances and oligopeptides in plasma, erythrocytes, and urine, depending on body weight. In obese individuals, there was a significant increase in the concentrations of low and medium molecular weight substances and oligopeptides compared to those with normal body weight in all biological samples studied, indicating endogenous intoxication in the body of obese individuals.
About the Authors
V. M. Nikolaev
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
NIKOLAEV Vyacheslav Mikhailovich – PhD in Biology, senior researcher, Epidemiology of Chronic Nonnfectious Diseases Department
S. I. Sofronova
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
SOFRONOVA Sargylana Ivanovna – PhD in Medicine, Head of Scientific-Organizational and Information Publishing Department
E. V. Tomtosova
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
TOMTOSOVA Evgeniya Viktorovna – junior researcher, Epidemiology of Chronic Non-Infectious Diseases Department
E. K. Rumyantsev
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
RUMYANTSEV Egor Konstantinovich – junior researcher, Arctic Medical Center
N. A. Sleptsova
Arctic State Agrotechnological University
Russian Federation
Russian Federation
SLEPTSOVA Natalia Alekseevna – PhD in Agriculture, Associate Professor, Head of the Department of Agronomy and Chemistry
References
1. Azhimamatova J.T. Possibilities of reducing endogenous intoxication during neoadjuvant polychemotherapy in patients with locally advanced cervical cancer // Bulletin of Osh State University. 2021. Vol. 1, No. 5. P. 12-21. DOI 10.52754/16947452_2021_1_5_12.
2. Bryukhanov V.M., Ulyanov G.P. The effect of glucagon on kidney function in experiments // Pharmacology and Toxicology. 1982. Vol. 45, No. 5. P. 73-77.
3. Malakhova M.Ya. Endogenous intoxication as a reflection of compensatory restructuring of metabolic processes in the body // Efferent Therapy. 2000. Vol. 6, No. 4. P. 3-14.
4. Margity M.M., Marzhokhova M.Yu., Khadzegova S.B. The significance of the content of substances of low and medium molecular weight and oligopeptides in the pathogenesis of chickenpox // Medical-Pharmaceutical Journal Pulse. 2021. Vol. 23, No. 6. P. 185-192. DOI 10.26787/nydha-2686-6838-2021-23-6-185-192.
5. Nikolaev V.M., Chirikova N.K., Sofrona S.I., et al. Prospective natural compounds as potential means of prevention and treatment of the new coronavirus infection caused by SARS-CoV-2 // Yakut Medical Journal. 2020. No. 3 (71). P. 95-101. DOI 10.25789/YMJ.2020.71.25.
6. Drapkina O.M., Kontseva A.V., Kalinina A.M., et al. Prevention of chronic non-infectious diseases in the Russian Federation. National Guidelines 2022 // Cardiovascular Therapy and Prevention. 2022. Vol. 21, No. 4. P. 5-232. DOI 10.15829/1728-8800-2022-3235.
7. Prokofieva T.V., Bashkina O.A., Polunina O.S., et al. The level of substances of medium and low molecular weight and oligopeptides in patients with myocardial infarction against the background of chronic obstructive pulmonary disease with single and multisystemic coronary artery lesions // Bulletin of Modern Clinical Medicine. 2022. Vol. 15, No. 2. P. 49-59. DOI 10.20969/VSKM.2022.15(2).49-59.
8. Efremova S.D., Nikolaev V.M., Romanova A.N., et al. Level of tumor markers in the blood serum of elderly population of the Republic of Sakha (Yakutia) suffering from obesity // Bulletin of the Ural Medical Academic Science. 2019. Vol. 16, No. 2. P. 116-121. DOI 10.22138/2500-0918-2019-16-2-116-121.
9. Faulkner JL. Obesity-associated cardiovascular risk in women: hypertension and heart failure. Clin Sci (Lond). 2021;135(12):1523-1544. doi:10.1042/CS20210384
10. Margraf A, Ludwig N, Zarbock A, Rossaint J. Systemic Inflammatory Response Syndrome After Surgery: Mechanisms and Protection //Anesth Analg. 2020;131(6):1693-1707. doi:10.1213/ANE.0000000000005175
11. Palanivel JA, Millington GWM. Obesity-induced immunological effects on the skin // Skin Health Dis. 2023;3(3):e160. Published 2023 Feb 28. doi:10.1002/ski2.160
12. Turayev UR, Kadirova LV. Degree of endogenic intoxication and microcirculation of blood in the liver with experimental acute intestinal obstruction // New Day in Medicine. 2021. No. 2(34). P. 128-131.
13. Zeng J, Sauter ER, Li B. FABP4: A New Player in Obesity-Associated Breast Cancer. Trends Mol Med. 2020;26(5):437-440. doi:10.1016/j.molmed.2020.03.004
Review
For citations:
Nikolaev V.M., Sofronova S.I., Tomtosova E.V., Rumyantsev E.K., Sleptsova N.A. The level of endogenous intoxication in overweight individuals. Yakut Medical Journal. 2023;(3):114-117. https://doi.org/10.25789/YMJ.2023.83.28
Views:
22
Email this article 