Clinical case of Willebrand disease combined with Crohn's disease in an adolescent Sakha
https://doi.org/10.25789/YMJ.2024.86.26
Abstract
The article presents an interesting clinical case of Willebrand's disease in combination with Crohn's disease and congenital heart disease in a 17-year-old Sakha teenager. Such clinical cases are rare in the public literature, since the combination of these diseases is practically not found. The onset of Crohn's disease at the age of 16 significantly affected the development and severity of clinical manifestations. Therapy with a genetically engineered biological drug and substitution therapy made it possible to achieve clinical and laboratory remission.
Keywords
Willebrand,
s disease,
Von Willebrand,
s factor,
homeostasis,
Crohn,
s disease,
congenital heart disease
About the Authors
M. S. Savvina
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Savvina Maya Semyenovna – PhD in Medicine, Senior Researcher, Laboratory for Monitoring Children's Health
O. N. Ivanova
Department of Pediatrics and Pediatric Surgery, M.K. Ammosov NEFU Medical Institute
Russian Federation
Russian Federation
Ivanova Olga Nicolaevna – MD, Professor
G. M. Melchanova
Pediatric Center RH No.1 – National Centre of Medicine
Russian Federation
Russian Federation
Melchanova Galina Mikchailovna – gastroenterologist
I. S. Ivanova
M.K. Ammosov NEFU Medical Institute
Russian Federation
Russian Federation
Ivanova Irina Semyenovna – 4th year student
T. E. Burtseva
Department of Pediatrics and Pediatric Surgery, M.K. Ammosov NEFU Medical Institute
Russian Federation
Russian Federation
Burtseva Tatyana Egorovna – MD, Professor
References
1. Grishechkina I.A., Polomoshnova T.N. Combination of ulcerative colitis and Willebrand disease (clinical observation) // Archives of internal medicine. 2017. No. 4. P. 313 – 317. Doi: 10.20514/2226-6704-2017-7-4-313-317.
2. Scherbakova O.V., Razumovsky A.Y., Shumilov P.V. Crohns disease in children: epidemiology, classification, diagnostic, indications for surgery // Pediatrics. 2017. T. 96. No. 6. P. 157 165. Doi: 10.24110/0031-403X-2017-96-6-157-165.
3. Blood disorders in patients undergoing transcatheter aortic valve replacement: A Review / De Larochelliere et al. // JACC Cardiovasc Interv. 2019. 12 (1). P. 1 – 11. Doi: 10.1016/j.jcin.2018.09.041.
4. Diagnosis and management of acquired von Willebrand disease in Heart disease: a review of the literature / Petricevic M. [et al] // Thorac Cardiovasc Surg. 2020. 68(3). P. 200 – 211. Doi: 10.1055/s–0038–1673670.
5. Federici A.B. The safety of plasma – derived Von Willebrand / factor VIII concentrates in the management of inherited Von Willebrand disease // J. Exp.Opinion on Drag Saf. 2009. Vol.8. P. 203 – 210. Doi:101517/14740330902719481.
6. Higher rates of bleeding and use of treatment products among young boys compared to girls with von Willebrand disease / Karon Abe et al. // J. Hematology. 2020. V95 (1). P. 10 – 17. Doi: 10.1002/ajh.25656.
7. Managemant of von Willebrand disease in patients undergoing total hip and knee arthroplasty / Yaghmour K.M. [et al.] // J Perioper Pract. 2019. 29(9). P. 266 – 269. Doi: 10.1177/1750458918820793.
8. Mechanisms of thrombocytopenia in platelet-type von Willebrand disease / Bury L. [et al.] // Haematologica. 2019. 104(7). P. 1473 – 1481. Doi: 10.3324/haemotol.2018.200378.
9. Mezzano D., Quiroga T. Diagnostic challenges of inherited mild bleeding disorders: a bait for poorly explored clinical and basic research // J. Thromb Yaemost. 2019. Feb.; 17(2). P. 257 – 270. Doi: 10.1111/jth.14363.
10. Sabih A., Babiker H.M. Von Willebrand desease //stat Pearls Publishing; 2021. Jan. PMID: 29083708.
11. Von Willebrand factor / ADAMTS-13 interactions at birth: implications for thrombosis in the neonatal period / Katneni U.K. [et al.] // J Thromb Haemost. 2019. 17(3). P. 429 – 440. Doi: 10.1111/jth.14374.
Review
For citations:
Savvina M.S., Ivanova O.N., Melchanova G.M., Ivanova I.S., Burtseva T.E. Clinical case of Willebrand disease combined with Crohn's disease in an adolescent Sakha. Yakut Medical Journal. 2024;(2):108-110. https://doi.org/10.25789/YMJ.2024.86.26
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