Transcriptome profiling of circulating immune cells in prostate cancer at single-cell resolution
E. R. Akramova,
Yu. V. Sharifyanova,
D. Kh. Gainullina,
P. N. Shmelkova,
V. Yu. Korobeinikov,
V. N. Pavlov,
K. I. Enikeeva https://doi.org/10.25789/YMJ.2026.93.02
Abstract
The study of the transcriptomic profile of circulating immune cells in patients with prostate cancer using single-cell RNA sequencing is conducted. In patients with prostate cancer, highly expressed genes were found in the monocyte cluster: IRAK3, PLXDC2, NAMPT, CYBB, SLC8A1 responsible for the activation of antitumor immunity, inflammation, and oxidative stress, while in healthy volunteers the expression of FCN1, MNDA, LST1, and AIF1 genes responsible for the activation of inflammation [1], modulation, and regulation were observed apoptosis [2, 3], growth of vascular smooth muscle cells and T-lymphocytes [4]. Analysis of the transcriptome of circulating immune cells in the peripheral blood of patients with prostate cancer revealed highly expressed genes IRAK3, PLXDC2, NAMPT, CYBB, SLC8A1, which play an important role in tumor progression and evasion of the immune response. These genes can serve as targeted targets for therapy and have diagnostic potential.
About the Authors
E. R. Akramova
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
Yu. V. Sharifyanova
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
D. Kh. Gainullina
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
P. N. Shmelkova
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
V. Yu. Korobeinikov
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
V. N. Pavlov
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
K. I. Enikeeva
Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Akramova E.R., Sharifyanova Yu.V., Gainullina D.Kh., Shmelkova P.N., Korobeinikov V.Yu., Pavlov V.N., Enikeeva K.I. Transcriptome profiling of circulating immune cells in prostate cancer at single-cell resolution. Yakut Medical Journal. 2026;(1):10-15. (In Russ.) https://doi.org/10.25789/YMJ.2026.93.02
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