ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2026.93.02ymj-3175Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПрофилирование транскриптома единичных циркулирующих иммунных клеток при раке простатыTranscriptome profiling of circulating immune cells in prostate cancer at single-cell resolutionhttps://orcid.org/0009-0000-1289-9365АкрамоваЭ. Р.AkramovaE. R.

Акрамова Элина Ринатовна ‒ мл. науч. сотр. лаборатории иммунологии, 

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

erakramova@bashgmu.ruhttps://orcid.org/0009-0000-8184-6072ШарифьяноваЮ. В.SharifyanovaYu. V.

Шарифьянова Юлия Вакилевна ‒ мл. науч. сотр. лаборатории иммунологии,

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

https://orcid.org/0009-0002-9174-4824ГайнуллинаД. Х.GainullinaD. Kh.

Гайнуллина Диана Халиловна ‒ лаборантисследователь лаборатории иммунологии, студент 5 курса педиатрического факультета, 

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

https://orcid.org/0009-0001-3298-3895ШмельковаП. Н.ShmelkovaP. N.

Шмелькова Полина Николаевна ‒ лаборант-исследователь лаборатории иммунологии, студент 5 курса педиатрического факультета, 

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

КоробейниковВ. Ю.KorobeinikovV. Yu.

Коробейников Вячеслав Юрьевич ‒ мл. науч. сотр. лаборатории иммунологии,

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

https://orcid.org/0000-0003-2125-4897ПавловВ. Н.PavlovV. N.

Павлов Валентин Николаевич ‒ акад. РАН, д-р мед. наук, проф., ректор,

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

https://orcid.org/0000-0002-5995-2124ЕникееваК. И.EnikeevaK. I.

Еникеева Кадрия Ильдаровна ‒ канд. фарм. наук, зав. лабораторией иммунологии,

ул. Шафиева, 2, корп. 5, г. Уфа, 450083

Институт урологии и клинической онкологии ФГБОУ ВО БГМУ Минздрава РоссииРоссия202628032026011015Copyright © Акрамова Э.Р., Шарифьянова Ю.В., Гайнуллина Д.Х., Шмелькова П.Н., Коробейников В.Ю., Павлов В.Н., Еникеева К.И., 20262026Акрамова Э.Р., Шарифьянова Ю.В., Гайнуллина Д.Х., Шмелькова П.Н., Коробейников В.Ю., Павлов В.Н., Еникеева К.И.Akramova E.R., Sharifyanova Y.V., Gainullina D.K., Shmelkova P.N., Korobeinikov V.Y., Pavlov V.N., Enikeeva K.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/3175

Проведено исследование транскриптомного профиля циркулирующих иммунных клеток (ЦИК) у пациентов с раком простаты методом single-cell RNA-секвенирования. У пациентов с раком простаты в кластере моноцитов были обнаружены высокоэкспрессированные гены: IRAK3, PLXDC2, NAMPT, CYBB, SLC8A1, отвечающие за активацию противоопухолевого иммунитета, воспаление и окислительный стресс, при этом у здоровых добровольцев наблюдалась экспрессия генов FCN1, MNDA, LST1, AIF1, отвечающих за активацию воспаления [1], модуляцию и регуляцию апоптоза [2, 3], рост сосудистых гладкомышечных клеток и Т-лимфоцитов [4]. Анализ транскриптома ЦИК периферической крови пациентов с раком предстательной железы выявил высокоэкспрессированные гены IRAK3, PLXDC2, NAMPT, CYBB, SLC8A1, которые играют важную роль в прогрессировании опухоли и уклонении от иммунного ответа. Эти гены могут служить целевыми мишенями для терапии и обладать диагностическим потенциалом.

The study of the transcriptomic profile of circulating immune cells in patients with prostate cancer using single-cell RNA sequencing is conducted. In patients with prostate cancer, highly expressed genes were found in the monocyte cluster: IRAK3, PLXDC2, NAMPT, CYBB, SLC8A1 responsible for the activation of antitumor immunity, inflammation, and oxidative stress, while in healthy volunteers the expression of FCN1, MNDA, LST1, and AIF1 genes responsible for the activation of inflammation [1], modulation, and regulation were observed apoptosis [2, 3], growth of vascular smooth muscle cells and T-lymphocytes [4]. Analysis of the transcriptome of circulating immune cells in the peripheral blood of patients with prostate cancer revealed highly expressed genes IRAK3, PLXDC2, NAMPT, CYBB, SLC8A1, which play an important role in tumor progression and evasion of the immune response. These genes can serve as targeted targets for therapy and have diagnostic potential.

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The authors declare that there are no conflicts of interest present.