Modern concepts about apoptosis
https://doi.org/10.25789/YMJ.2023.83.24
Abstract
The review is devoted to the generalization of modern knowledge about such a type of cell death as apoptosis. To date, it is known that apoptosis is not just a programmed cell death that ensures the elimination of old cells with minimal damage to surrounding tissues, but it is also a complex mechanism that can promote survival and proliferation, as well as induce and suppress the inflammatory process. Drugs that cause enhanced apoptosis are being actively studied for the treatment of oncological diseases. The mechanisms of cell death selection are still being studied, but it is already known that weak effects on the macroorganism promote the activation of apoptosis and autophagy, while stronger effects promote necrosis. Low levels of apoptosis contribute to the accumulation of damaged cells, aging, and genome instability. Reduced accumulation of senescent cells improves homeostasis and lifespan.
About the Authors
E. V. Kontievskaya
N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Institute of Physiology of Natural Adaptations
Russian Federation
Russian Federation
KONTIEVSKAYA Elena Vladimirovna – junior researcher
V. P. Patrakeeva
N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Institute of Physiology of Natural Adaptations
Russian Federation
Russian Federation
PATRAKEEVA Veronika Pavlovna – PhD in Biology, chief researcher, head of the Laboratory of Ecological Immunology
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Review
For citations:
Kontievskaya E.V., Patrakeeva V.P. Modern concepts about apoptosis. Yakut Medical Journal. 2023;(3):97-101. https://doi.org/10.25789/YMJ.2023.83.24
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