Paget’s disease of bone as a rare cause of headache
https://doi.org/10.25789/YMJ.2025.92.31
Abstract
Headache is one of the most common complaints in clinical practice. While primary headaches (such as tension-type headache and migraine) are the most prevalent, timely identification of secondary headaches is crucial, as they require a different diagnostic and therapeutic approach. This article presents a clinical case of a patient whose only manifestation of Paget’s disease of bone was headache. Based on elevated serum alkaline phosphatase levels, a more thorough examination was performed in a 47-year-old patient initially diagnosed with tension-type headache. MRI, CT of the brain, and bone scintigraphy allowed the diagnosis of Paget’s disease of bone to be established and pathogenetic therapy to be initiated.
About the Authors
A. I. Vasiliev
ГАУ РС(Я) «Республиканская больница №1 – Национальный центр медицины им. М.Е. Николаева»
Russian Federation
Russian Federation
A. A. Tappakhov
ФГАОУ ВО «Северо-Восточный федеральный университет им. М.К. Аммосова»; ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
T. E. Popova
ГАУ РС(Я) «Республиканская больница №1 – Национальный центр медицины им. М.Е. Николаева»
Russian Federation
Russian Federation
References
1. Kondratyev A.V., Schnayder N.A., Shulmin A.V. Epidemiology of headaches // Modern problems of science and education. 2015; Vol. 6. P. 23–35.
2. Appelman-Dijkstra N.M., Papapoulos S.E. Paget’s disease of bone // Best Pract Res Clin Endocrinol Metab. 2018. T. 32, Vol. 5. P. 657–668. doi:10.1016/j.beem.2018.05.005
3. Choi Y.J., Sohn Y.B., Chung Y-S. Updates on Paget’s Disease of Bone // Endocrinol Metab. 2022. T. 37, Vol. 5. P. 732–743. doi:10.3803/EnM.2022.1575
4. Corral-Gudino L., Borao-Cengotita-Bengoa M., Del Pino-Montes J., Ralston S. Epidemiology of Paget’s disease of bone: A systematic review and meta-analysis of secular changes. Bone. 2013. T. 55, Vol. 2. P. 347–352. doi:10.1016/j.bone.2013.04.024
5. Evangelatos G., Iliopoulos A.Headache in patients with Paget’s disease of bones // J. Frailty Sarcopenia Falls. 2017. Vol. 2(2). P. 16–20.
6. Faruch Bilfeld M., Lapègue F., Chiavassa Gandois H., et al. Paget's Disease or Densifying Metastasis: How to Sort It Out. Semin Musculoskelet Radiol. 2023. T. 27, Vol. 4. P. 480-486. doi: 10.1055/s-0043-1771036.
7. Gennari L., Rendina D., Falchetti A., Merlotti D. Paget’s Disease of Bone. Calcif Tissue Int. 2019. T. 104, Vol. 5. P. 483–500. doi:10.1007/s00223-019-00522-3
8. Hernandez J., Molina E., Rodriguez A., et al. Headache Disorders: Differentiating Primary and Secondary Etiologies. J Integr Neurosci. 2024. T. 23, Vol. 2. doi:10.31083/j.jin2302043
9. Morissette J., Laurin N., Brown J.P. Sequestosome 1: Mutation Frequencies, Haplotypes, and Phenotypes in Familial Paget’s Disease of Bone // J Bone Miner Res. 2006. T. 21, Vol. S2. P. 38-44. doi:10.1359/jbmr.06s207
10. Nebot Valenzuela E., Pietschmann P. Epidemiology and pathology of Paget's disease of bone - a review // Wien Med. Wochenschr. 2016. T. 167. P. 2–8. doi: 10.1007/s10354-016-0496-4
11. Ouhabi D., Tibar H., Benomar A., et al. Headache and Status Epilepticus Reveal Paget’s Disease of the Bone. Cureus. doi:10.7759/cureus.60588
12. Rubin D.J., Levin R.M. Neurologic Complications of Paget Disease of Bone // Endocr Pract. 2009. T. 15, Vol. 2. P.158–166. doi:10.4158/EP.15.2.158
13. Saylor D., Steiner T. The Global Burden of Headache // Semin Neurol. 2018. T. 38, Vol. 02. P. 182–190. doi:10.1055/s-0038-1646946
14. Stovner L.J., Hagen K., Linde M., Steiner T.J. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain. 2022. T. 23, Vol. 1. P. 34. doi:10.1186/s10194-022-01402-2
15. Tan A., Ralston S.H. Clinical Presentation of Paget’s Disease: Evaluation of a Contemporary Cohort and Systematic Review // Calcif Tissue Int. 2014. T. 95, Vol. 5. P. 385–392. doi:10.1007/s00223-014-9904-1
16. Vallet M., Ralston S. H. Biology and treatment of Paget's disease of bone // J. Cell Biochem. 2016. Vol. 117. P. 289–299. doi:10.1002/jcb.25291
17. Varenna M., Zucchi F., Galli L., et al. Demographic and Clinical Features Related to a Symptomatic Onset of Paget’s Disease of Bone. J Rheumatol. 2010. T. 37, Vol. 1. P. 155–160. doi:10.3899/jrheum.090674
Review
For citations:
Vasiliev A.I., Tappakhov A.A., Popova T.E. Paget’s disease of bone as a rare cause of headache. Yakut Medical Journal. 2025;(4):141-143. (In Russ.) https://doi.org/10.25789/YMJ.2025.92.31
Views:
25
JATS XML
Email this article 