Histologic changes of the placenta in chronic subcompensated placental insufficiency in women with COVID-19 of moderate severity in the second and third trimesters of pregnancy
https://doi.org/10.25789/YMJ.2025.92.02
Abstract
The histologic study of placental tissues in women with subcompensated chronic placental insufficiency associated with moderate COVID-19 was conducted. Histologic study of placenta from women of the main group revealed the following uncharacteristic specific signs of viral tissue damage: decidual vasculopathy, lymphoplasmacytic infiltration, thrombi in the venous vessels of the stem villi, villitis and intervillusitis, deposition of intervillous fibrinoid, hyperplasia of syncytiotrophoblast and chorangiosis. Morphometric analysis showed an increase in the proportion of perivorsinchal fibrin and capillaries in terminal villi, and a decrease in the density of syncytiotrophoblast membranes. In addition, an increase in the number of syncytial nodules and intermediate immature villi, as well as capillary bleeding in intermediate and terminal villi were found. The moderately severe course of COVID-19 in the second and third trimesters of pregnancy is associated with structural changes in the placenta, which, with insufficient efficiency of compensatory and adaptive mechanisms, is one of the causes of the development of subcompensated chronic placental insufficiency.
About the Authors
I. A. Andrievskaya
ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»
Russian Federation
Russian Federation
T. S. Churikova
ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»
Russian Federation
Russian Federation
O. L. Kutepova
ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»
Russian Federation
Russian Federation
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Review
For citations:
Andrievskaya I.A., Churikova T.S., Kutepova O.L. Histologic changes of the placenta in chronic subcompensated placental insufficiency in women with COVID-19 of moderate severity in the second and third trimesters of pregnancy. Yakut Medical Journal. 2025;(4):13-17. (In Russ.) https://doi.org/10.25789/YMJ.2025.92.02
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