Clinical and morphological features of desmoid-type fibromatosis
https://doi.org/10.25789/YMJ.2025.92.25
Abstract
In order to study the clinical and morphological features of fibromatosis of the desmoid type, a literature review was conducted. It was found that fibromatosis of the desmoid type is a locally ag-gressive myofibroblastic tumor that occurs in muscular-aponeurotic structures. The clinical picture is affected by the localization of the tumor and its invasive growth into the surrounding tissues.
The complexity of diagnosis is due to the rarity and morphological similarity to soft tissue sarcomas. Immunohistochemical research is used to exclude malignancy. It was found that the features of fibromatosis of the desmoid type are characterized by pronounced diffuse nuclear expression of beta-catenin, reactions to DOG1, CD117, S-100 and SMA are negative.
About the Authors
N. B. Pilkevich
ФГБОУ ВО Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
R. R. Khabibullin
ФГБОУ ВО Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
V. A. Markovskaya
ФГБОУ ВО Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
O. V. Yavorskaya
ФГБОУ ВО Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
A. P. Smirnova
ФГБОУ ВО Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
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Review
For citations:
Pilkevich N.B., Khabibullin R.R., Markovskaya V.A., Yavorskaya O.V., Smirnova A.P. Clinical and morphological features of desmoid-type fibromatosis. Yakut Medical Journal. 2025;(4):118-122. (In Russ.) https://doi.org/10.25789/YMJ.2025.92.25
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