ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2025.92.25ymj-3042Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSКлинико-морфологические особенности фиброматоза десмоидного типаClinical and morphological features of desmoid-type fibromatosishttps://orcid.org/0000-0001-7260-4629ПилькевичН. Б.PilkevichN. B.

Пилькевич Наталья Борисовна – д.м.н., проф. Мед. института.

308015, Белгород, ул. Победы, д. 85

pilkevich@bsuedu.ruhttps://orcid.org/0000-0002-0887-2378ХабибуллинР. Р.KhabibullinR. R.

Хабибуллин Руслан Равильевич – ст. преподаватель Мед. института; зав. отд. ОГБУЗ «Белгородское патологоанатомическое бюро».

308015, Белгород, ул. Победы, д. 85

habibullin@bsuedu.ruhttps://orcid.org/0000-0003-4410-9318МарковскаяВ. А.MarkovskayaV. A.

Марковская Вера Александровна – к.б.н., зав. кафедрой Мед. института.

308015, Белгород, ул. Победы, д. 85

markovskaya@bsuedu.ruhttps://orcid.org/0009-0003-3288-9289ЯворскаяО. В.YavorskayaO. V.

Яворская Ольга Владимировна – преподаватель мед. колледжа Мед. института.

308015, Белгород, ул. Победы, д. 85

yavorskaya@bsuedu.ruhttps://orcid.org/0009-0001-3087-0037СмирноваА. П.SmirnovaA. P.

Смирнова Анастасия Павловна – студентка Мед. института.

308015, Белгород, ул. Победы, д. 85

1330007@bsuedu.ruФГБОУ ВО Белгородский государственный национальный исследовательский университетRussian Federation20253012202504118122Copyright © Пилькевич Н.Б., Хабибуллин Р.Р., Марковская В.А., Яворская О.В., Смирнова А.П., 20252025Пилькевич Н.Б., Хабибуллин Р.Р., Марковская В.А., Яворская О.В., Смирнова А.П.Pilkevich N.B., Khabibullin R.R., Markovskaya V.A., Yavorskaya O.V., Smirnova A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/3042

С целью изучения клинико-морфологических особенностей фиброматоза десмоидного типа проведен анализ литературы. Установлено, что фиброматоз десмоидного типа является локально агрессивной миофибробластной опухолью, возникающей в мышечно-апоневротических структурах. На клиническую картину влияет локализация опухоли и её инвазивный рост в окружающие ткани.

Сложность диагностики обусловлена редкостью и морфологическим сходством с саркомами мягких тканей. С целью исключения злокачественного новообразования используется иммуногистохимическое исследование. Установлено, что для особенностей фиброматоза десмоидного типа характерна выраженная диффузная ядерная экспрессия бета-катенина, реакции на DOG1, CD117, S-100 и SMA негативны.

In order to study the clinical and morphological features of fibromatosis of the desmoid type, a literature review was conducted. It was found that fibromatosis of the desmoid type is a locally ag-gressive myofibroblastic tumor that occurs in muscular-aponeurotic structures. The clinical picture is affected by the localization of the tumor and its invasive growth into the surrounding tissues.

The complexity of diagnosis is due to the rarity and morphological similarity to soft tissue sarcomas. Immunohistochemical research is used to exclude malignancy. It was found that the features of fibromatosis of the desmoid type are characterized by pronounced diffuse nuclear expression of beta-catenin, reactions to DOG1, CD117, S-100 and SMA are negative.

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The authors declare that there are no conflicts of interest present.