Researching connections of PRO12ALA polymorphic markers of the PPARγ2 gene with metabolic disorders in yakutia’s indigenous population
https://doi.org/10.25789/YMJ.2020.71.28
Abstract
The association of pro12Ala polymorphic markers of the PPARγ2 gene with metabolic syndrome and its components in the indigenous residents of Yakutia was studied. DNA samples of representatives of the Yakut nationality, permanently residing in the village Berdigestyakh of the Gorny Ulus of Yakutia were under study. Carriage of the Ala allele was quite often observed in the studied group. At the same time, in most cases, the Pro/Ala genotype was established, and only in 2 cases - Ala/Ala. This distribution is generally not very typical for Asian populations. The results of the study did not reveal statistically significant associations of polymorphic markers of the PPARγ2 gene (rs 1801282) with metabolic disorders.
About the Authors
E. P. Ammosova
Мединститут СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
T. M. Klimova
МИ СВФУ;
ЯНЦ КМП
Russian Federation
Russian Federation
A. I. Fedorov
Мединститут СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
M. E. Baltakhinova
Медицинская клиника «Аврора»
Russian Federation
Russian Federation
R. N. Zakharova
Мединститут СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
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Review
For citations:
Ammosova E.P., Klimova T.M., Fedorov A.I., Baltakhinova M.E., Zakharova R.N. Researching connections of PRO12ALA polymorphic markers of the PPARγ2 gene with metabolic disorders in yakutia’s indigenous population. Yakut Medical Journal. 2020;(3):111-114. (In Russ.) https://doi.org/10.25789/YMJ.2020.71.28
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