ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.71.28ymj-3000Research ArticleТОЧКА ЗРЕНИЯPOINT OF VIEWПоиск ассоциации полиморфных маркеров PRO12ALA гена PPARγ2 с метаболическими нарушениями у коренного населения ЯкутииResearching connections of PRO12ALA polymorphic markers of the PPARγ2 gene with metabolic disorders in yakutia’s indigenous populationhttps://orcid.org/0000-0002-7973-6103АммосоваЕ. П.AmmosovaE. P.

Аммосова Елена Петровна – к.м.н., в.н.с. НИЦ, доцент

ammosovael@mail.ruhttps://orcid.org/0000-0003-2746-0608КлимоваТ. М.KlimovaT. M.

Климова Татьяна Михайловна – к.м.н., доцент, с.н.с. 

biomedykt@mail.ruhttps://orcid.org/0000-0002-7973-6103ФедоровА. И.FedorovA. I.

Федоров Афанасий Иванович – к.б.н., с.н.с.

fedorow@yandex.ruhttps://orcid.org/0000-0003-0986-7754БалтахиноваМ. Е.BaltakhinovaM. E.

Балтахинова Марина Егоровна – врач терапевт,

г. Якутск

bmeg@rambler.ruhttps://orcid.org/0000-0002-1395-8256ЗахароваР. Н.ZakharovaR. N.

Захарова Раиса Николаевна – к.м.н., в.н.с.

prn.inst@mail.ruМединститут СВФУ им. М.К. АммосоваРоссияМИ СВФУ; ЯНЦ КМПРоссияМедицинская клиника «Аврора»Россия20201112202503111114Copyright © Аммосова Е.П., Климова Т.М., Федоров А.И., Балтахинова М.Е., Захарова Р.Н., 20252025Аммосова Е.П., Климова Т.М., Федоров А.И., Балтахинова М.Е., Захарова Р.Н.Ammosova E.P., Klimova T.M., Fedorov A.I., Baltakhinova M.E., Zakharova R.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/3000

Изучена ассоциация полиморфных маркеров pro12Ala гена PPARγ2 с метаболическим синдромом и его компонентами у коренных жителей Якутии. Исследованы образцы ДНК представителей якутской национальности, постоянно проживающих в с. Бердигестях Горного улуса Якутии. В изученной группе достаточно часто наблюдалось носительство аллеля Ala. При этом в большинстве случаев был установлен генотип Pro/Ala и только в 2 случаях - Ala/Ala. Такое распределение в целом является не очень характерным для азиатских популяций. Результаты исследования не выявили статистически значимых ассоциаций полиморфных маркеров гена PPARγ2 (rs 1801282) с метаболическими нарушениями.

The association of pro12Ala polymorphic markers of the PPARγ2 gene with metabolic syndrome and its components in the indigenous residents of Yakutia was studied. DNA samples of representatives of the Yakut nationality, permanently residing in the village Berdigestyakh of the Gorny Ulus of Yakutia were under study. Carriage of the Ala allele was quite often observed in the studied group. At the same time, in most cases, the Pro/Ala genotype was established, and only in 2 cases - Ala/Ala. This distribution is generally not very typical for Asian populations. The results of the study did not reveal statistically significant associations of polymorphic markers of the PPARγ2 gene (rs 1801282) with metabolic disorders.

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The authors declare that there are no conflicts of interest present.