Contribution of certain biochemical and immunological indicators to the development of arterial hypertension and obesity in Arctic residents
https://doi.org/10.25789/YMJ.2020.71.21
Abstract
A study of the association of certain biochemical and immunological parameters with abdominal obesity and arterial hypertension was carried in indigenous peoples of the North of the Arctic territory of Yakutia. The data show that hypertensive patients have a high frequency of abdominal obesity, high cholesterol due to the atherogenic fraction. A statistically significant reliable relationship was revealed between the levels of glucose and lipids with waist size and systolic blood pressure. Significant correlation of pro-inflammatory cytokine IL-6 with abdominal obesity in hypertensive patients was obtained.
About the Authors
S. I. Sofronova
ЯНЦ КМП
Russian Federation
Russian Federation
V. M. Nikolaev
ЯНЦ КМП
Russian Federation
Russian Federation
M. P. Kirillina
ЯНЦ КМП
Russian Federation
Russian Federation
A. N. Romanova
ЯНЦ КМП
Russian Federation
Russian Federation
References
1. V.P. Inflammation, immunocompetent cells, cytokines - a role in atherogenesis / V.P. Karagodin, Yu.V. Bobryshev, A.N. Orekhov // Pathogenesis. - 2014. - №1 (12). - P.21-35.
2. Klimova T.M. Obesity criteria for identifying metabolic risk factors among indigenous rural population of Yakutia / T.M. Klimova, V.I. Fedorova, M.E. Baltakhinova // Siberian medical journal.- 2012. - №8. - P.110-113.
3. Russian Statistical Yearbook. М. - 2018. - 694 p.
4. Sofronova S.I. Arterial hypertension and metabolic syndrome in small indigenous people of the North of Yakutia / S.I. Sofronova // Yakut medical journal. - 2018. - №1. - P.14-17. DOI 10.25789/YMJ.2018.61.03
5. Shalenkova M.A. Role of markers of necrosis and inflammation in predicting acute forms of coronary heart disease / M.A. Shalenkova, Je.T. Muhametova, Z.D. Mikhailova // Clinical medicine - 2013. - №91 (11). - P. 14-20.
6. Andrade R., Gigante D., Oliveira I. and Horta B.C-Peptide and cardiovascular risk factors among young adults in a southern Brazilian cohort. BMC Endocrine Disorders, 2018. 18:80. https://doi.org/10.1186/s12902-018-0308-5
7. Beverly JK, Budoff MJ. Atherosclerosis: Pathophysiology of Insulin Resistance, Hyperglycemia, Hyperlipidemia, and Inflammation. J Diabetes. 2020 Feb;12 (2):102-104. doi: 10.1111/1753-0407.12970
8. Bisoendial R et al. C-reactive protein is a mediator of cardiovascular disease. Europ Heart J. 2010; 31(17): 2087–95.
9. Blake G, Ridker P. Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med. 2002; 252(4): 283-94.
10. Bloomgarden ZT. Insulin Resistance, Dyslipidemia, and Cardiovascular Disease. Diabetes Care. 2007 Aug; 30 (8): 2164-70. doi: 10.2337/dc07-zb08.
11. Eddy D, Schlessinger L, Kahn R. et al. Relationship of Insulin Resistance and Related Metabolic Variables to Coronary Artery Disease: A Mathematical Analysis. Diabetes Care. 2009; 32(2): 361-6. doi: 10.2337/dc08-0854
12. Forouzanfar M, Liu P, Roth G. et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990- 2015. JAMA. 2017; 317(2): 165-182. https://doi.org/10.1001/jama.2016.19043
13. Hirai FE, Moss SE, Klein BE, Klein R. Relationship of glycemic control, exogenous insulin, and C-Peptide levels to ischemic heart disease mortality over a 16-year period in people with older-onset diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR). Diabetes Care. 2008; 31(3):493–7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773445/
14. Koenig W, Lowel H, Baumert J, Meisinger C. C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany. Circulation. 2004; 109: 1349–53.
15. Laakso M, Kuusisto J, Stančáková A. et al. The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res. 2017; 58(3): 481–493. DOI 10.1194/jlr.O072629
16. Pai J et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med. 2004; 351: 2599–610.
17. Patel N, Taveira TH, Choudhary G, Whitlatch H, Wu WC. Fasting serum C-Peptide levels predict cardiovascular and overall death in nondiabetic adults. J Am Heart Assoc. 2012; 1(6):e003152. https://doi.org/10.1161/JAHA.112.003152
18. Purohit P, Mathur R. Hypertension association with serum lipoproteins, insulin, insulin resistance and C-peptide: Unexplored forte of cardiovascular risk in hypothyroidism. North Am J Med Sci. 2013; 5: 195-201.
19. Reaven G. Insulin Resistance and Coronary Heart Disease in Nondiabetic Individuals. Arterioscler Thromb Vasc Biol. 2012. Aug; 32(8):1754-9. doi: 10.1161/ATVBAHA.111.241885.
20. Ridker PM, Rifai N, Rose L, Buring J, Cook N. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002; 347:1557–65.
21. Yan W, Song Y, Zhou L. et al. Immune cell repertoire and their mediators in patients with acute myocardial infarction or stable angina pectoris. Int. J. Med. Sci. 2017; 14(2): 181-190. DOI: 10.7150/ijms.17119.
Review
For citations:
Sofronova S.I., Nikolaev V.M., Kirillina M.P., Romanova A.N. Contribution of certain biochemical and immunological indicators to the development of arterial hypertension and obesity in Arctic residents. Yakut Medical Journal. 2020;(3):80-83. (In Russ.) https://doi.org/10.25789/YMJ.2020.71.21
Views:
6
Email this article 