Frequencies Polymorphism of Q192R of the paraoxonase 1 gene of different ethnic groups of Eastern Siberia
https://doi.org/10.25789/YMJ.2020.71.19
Abstract
Paraoxonase 1 (PON1) is an enzyme, which involved in lipid metabolism and biotransformation of xenobiotics. It was reported that the Q192R polymorphism affects the activity of paraoxonase, determining the differential sensitivity to certain organophosphorus pesticides and the predisposition to diseases associated with lipid metabolism disorders. The aim of this study was to determine the frequency of alleles and genotypes of the Q192R polymorphism of PON1 gene in different populations of Eastern Siberia: Russians, Buryats, Evenks, Tofalars. Evenks, Tofalars and Buryats, belonging to the North Asian small race, form a separate cluster, distanced from the populations of the Far Eastern Mongoloids (Japanese, Koreans) and Caucasoid populations.
About the Authors
T. A. Bairova
ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»
г.Иркутск
Russian Federation
Russian Federation
O. A. Ershova
ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»
Russian Federation
Russian Federation
S. I. Kolesnikov
ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»
Russian Federation
Russian Federation
L. I. Kolesnikova
ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»
Russian Federation
Russian Federation
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Review
For citations:
Bairova T.A., Ershova O.A., Kolesnikov S.I., Kolesnikova L.I. Frequencies Polymorphism of Q192R of the paraoxonase 1 gene of different ethnic groups of Eastern Siberia. Yakut Medical Journal. 2020;(3):72-76. (In Russ.) https://doi.org/10.25789/YMJ.2020.71.19
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