ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.71.19ymj-2991Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICРаспространённость полиморфизма Q192R гена параоксоназы 1 в разных этнических группах Восточной СибириFrequencies Polymorphism of Q192R of the paraoxonase 1 gene of different ethnic groups of Eastern SiberiaБаироваТ. А.BairovaT. A.

Баирова Татьяна Ананьевна – д.м.н., руковод. лаб.

tbairova38@mail.ruЕршоваО. А.ErshovaO. A.

Ершова Оксана Александровна – к.б.н., н.с.

КолесниковС. И.KolesnikovS. I.

Колесников Сергей Иванович – академик РАН

КолесниковаЛ. И.KolesnikovaL. I.

Колесникова Любовь Ильинична – академик РАН, научн. руковод. Центра

ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека» г.ИркутскRussian FederationФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»Russian Federation202011122025037276Copyright © Баирова Т.А., Ершова О.А., Колесников С.И., Колесникова Л.И., 20252025Баирова Т.А., Ершова О.А., Колесников С.И., Колесникова Л.И.Bairova T.A., Ershova O.A., Kolesnikov S.I., Kolesnikova L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/2991

Параоксоназа 1 (PON1) участвует в метаболизме липидов и биотрансформации ксенобиотиков. Сообщалось, что полиморфизм Q192R влияет на активность параоксоназы, определяя дифференцированную чувствительность к некоторым фосфорорганическим пестицидам и предрасположенность к заболеваниям, связанным с нарушениями липидного обмена. Целью настоящего исследования явилось определение частоты аллелей и генотипов полиморфизма Q192R гена PON1 в разных популяциях Восточной Сибири: русские, буряты, эвенки, тофалары. Эвенки, тофалары и буряты, относящиеся к североазиатской малой расе, образуют отдельный кластер, дистанцированный от популяций дальневосточных монголоидов (японцы, корейцы) и европеоидных популяций.

Paraoxonase 1 (PON1) is an enzyme, which involved in lipid metabolism and biotransformation of xenobiotics. It was reported that the Q192R polymorphism affects the activity of paraoxonase, determining the differential sensitivity to certain organophosphorus pesticides and the predisposition to diseases associated with lipid metabolism disorders. The aim of this study was to determine the frequency of alleles and genotypes of the Q192R polymorphism of PON1 gene in different populations of Eastern Siberia: Russians, Buryats, Evenks, Tofalars. Evenks, Tofalars and Buryats, belonging to the North Asian small race, form a separate cluster, distanced from the populations of the Far Eastern Mongoloids (Japanese, Koreans) and Caucasoid populations.

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The authors declare that there are no conflicts of interest present.