The role of hsp70 and nitrogen oxide in realization of adaptogenic reactions on the model of acute emotional stress
https://doi.org/10.25789/YMJ.2020.71.03
Abstract
The role of heat shock proteins (Hsp70) and nitrogen oxide in realization of adaptive reactions and adaptogenic effect of the extract from Astragalus membranaceus (Fischer) Bunge containing flavonoids and triterpenes as active substance has been studied on the model of acute emotional stress. The course preventive administration of the extract from Astragalus membranaceus in experimental-therapeutic dose 50 mg/kg against the background of the acute emotional stress has a marked stress-protective effect preventing from the development of the “Selye’s triad”: involution of thymus, hypertrophy of the adrenal glands and erosive injury of the stomach mucosa. It has been shown that the activation of Hsp70 synthesis and prevention of stress-induced NO generation is the molecular-cell mechanism of increased resistance to stress due to the content of the given biologically active substances promoting activation of the heat shock proteins expression and having marked antioxidant properties.
About the Authors
E. A. Alekseeva
Бурятский гос. ун-т им. Доржи Банзарова
Russian Federation
Russian Federation
L. N. Shantanova
Ин-т общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
S. M. Nikolaev
Ин-т общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
I. Yu. Malyshev
Ин-т общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
I. E. Matkhanov
Ин-т общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
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Review
For citations:
Alekseeva E.A., Shantanova L.N., Nikolaev S.M., Malyshev I.Yu., Matkhanov I.E. The role of hsp70 and nitrogen oxide in realization of adaptogenic reactions on the model of acute emotional stress. Yakut Medical Journal. 2020;(3):15-18. (In Russ.) https://doi.org/10.25789/YMJ.2020.71.03
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