Cerebral amyloid angiopathy: case report
https://doi.org/10.25789/YMJ.2020.69.10
Abstract
Cerebral amyloid angiopathy (CAA) is a disease of the small cerebral vessels and it mostly affects older people. CAA is characterized by progressive deposition of amyloid-beta in small arteries and arteries of medium caliber, as well as in the capillaries. Sporadic amyloid angiopathy is a cause of recurrent cerebral hemorrhage and cognitive impairment in the elderly. The latest scientific researches and a case report of a patient who suffered from cerebral amyloid angiopathy were used in order to prepare this article. The diagnosis and treatment of CAA are considered.
About the Authors
A. A. Tappakhov
North-Eastern Federal University; Мedical Clinic of NEFU; Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
TAPPAKHOV Alexey A. – Candidate of Sciences in Medicine, Associate Professor at the Department of Neurology and Psychiatry of the Medical Institute; Head Researcher of the Laboratory of Neuropsychophysiological Researches; Senior Researcher, Center for Neurodegenerative Diseases
36, Kulavsky str., Yakutsk, 677000, Republic of Sakha (Yakutia)
T. E. Popova
Scientific Center for Complex Medical Problems; North-Eastern Federal University
Russian Federation
Russian Federation
POPOVA Tatyana E. – Grand PhD in Medical Sciences, deputy Director for Science; Professor at the Department of Neurology and Psychiatry of the Medical Institute
4, Sergellahskoe shosse, str, Yakutsk, 677019, Republic of Sakha (Yakutia)
M. N. Petrova
Republican Hospital Number №3, Yakutsk
Russian Federation
Russian Federation
PETROVA Maria N. – Head of the Geriatric Neurology Department of the Geriatric Center
37, Novopokrovsky trakt, str, Yakutsk, 677000, Republic of Sakha (Yakutia)
A. E. Steblevskaya
North-Eastern Federal University
Russian Federation
Russian Federation
STEBLEVSKAYA Anna E. – 2nd year resident in the specialty "Neurology" of the Department of Internal Medicine and General Practice (Family Medicine) of the Medical Institute
27, Oyunsky str., Yakutsk, 677016, Republic of Sakha (Yakutia)
S. A. Sleptsova
Republican Hospital Number №3, Yakutsk
Russian Federation
Russian Federation
SLEPTSOVA Sardaana A. – Neurologist, Department of Geriatric Neurology, Geriatric Center
37, Novopokrovsky trakt, str, Yakutsk, 677000, Republic of Sakha (Yakutia)
D. V. Shishigin
North-Eastern Federal University
Russian Federation
Russian Federation
SHISHIGIN Dmitriy V. – 2nd year resident in the specialty "Neurology" of the Department of Internal Medicine and General Practice (Family Medicine) of the Medical Institute
27, Oyunsky str, Yakutsk, 677016, Republic of Sakha (Yakutia)
E. E. Konnikova
North-Eastern Federal University; Мedical Clinic of NEFU
Russian Federation
Russian Federation
KONNIKOVA Ediliya E. – Candidate of Sciences in Medicine, Associate Professor at the Department of Neurology and Psychiatry of the Medical Institute; Head Researcher of the Laboratory of Neuropsychophysiological Researches
36, Kulavsky str., Yakutsk, 677000, Republic of Sakha (Yakutia)
References
1. Gutorova D.A. Screening for cognitive impairment in the elderly and senile using the 3-CT scale / D.A. Gutorova, E.E. Vasenina, O.S. Levin // S.S. Korsakov journal of neurology and psychiatry. – 2016. – Vol. 116 (5). – P. 35-40. DOI: 10.17116/jnevro20161166235-40
2. Diagnosis and treatment of Alzheimer’s disease / A.A. Naumenko, D.O. Gromova, N.V. Trofimova [et al.] // Neurology, neuropsychiatry, psychosomatics. – 2016. – Vol. 8(4). – P. 91-97. DOI: 10.14412/2074-2711-2016-4-91-97
3. Kulesh A.A. Hemorrhagic manifestations of cerebral amyloid angiopathy - from pathogenesis to clinical significance / A.A. Kulesh, V.E. Drobakha, V.V. Shestakov // Neurology, neuropsychiatry, psychosomatics. – 2018. – Vol. 10(3). – P. 4-11. DOI: 10.14412/2074-2711-2018-3-4-11
4. Parfenov V.A. Cognitive Impairment / V.A. Parfenov, V.V. Zakharov, I.S. Preobrazhenskaya. – M.: Remedium. – 2015. – 187 p.
5. Attems J. Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study / J. Attems, F. Lauda, К.А. Jellinger // J Neurol. – 2008. – Vol. 255(1). – P. 70-76. DOI: 10.1007/s00415-008-0674-4
6. Cerebral amyloid angiopathy pathology and cognitive domains in older persons / Z. Arvanitakis, S.E. Leurgans, Z. Wang [et al.] // Ann Neurol. – 2011. – Vol. 69(2). – P. 320-327. DOI: 10.1002/ana.22112
7. Cerebral amyloid angiopathy and cognitive outcomes in communitybased older persons / Р.А. Boyle, L. Yu, S. Nag [et al.] // Neurology. – 2015. – Vol. 85(22). – P. 1930-1936. DOI: 10.1212/WNL.0000000000002175
8. Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta analysis / А. Charidimou, J.O. Friedrich, S.M. Greenberg [et al.] // Neurology. – 2018. – Vol. 90(9). – P. 754-762. DOI: 10.1212/WNL.0000000000005030
9. Emerging concepts in sporadic cerebral amyloid angiopathy / А. Charidimou, G. Boulouis, М.Е. Gurol [et al.] // Brain. – 2017. – Vol. 140(7). – P. 1829-1850. DOI: 10.1093/brain/awx047
10. Greenberg S.M. Diagnosis of Cerebral Amyloid Angiopathy: Evolution of the Boston Criteria / S.M. Greenberg, А. Charidimou // Stroke. – 2018. – Vol. 49(2). – P. 491-497.
11. Jellinger K.A. Alzheimer disease and cerebrovascular pathology: an update / К.А. Jellinger // J. Neural. Transm (Vienna). – 2002. – Vol. 109(5-6). – P. 813-836. DOI: 10.1007/s007020200068
12. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration / J.M. Wardlaw, E.E. Smith, G.J. Biessels [et al.] // Lancet Neurol. – 2013. – Vol. 12(8). – P. 822-838. DOI: 10.1016/S1474-4422(13)70124-8
Review
For citations:
Tappakhov A.A., Popova T.E., Petrova M.N., Steblevskaya A.E., Sleptsova S.A., Shishigin D.V., Konnikova E.E. Cerebral amyloid angiopathy: case report. Yakut Medical Journal. 2020;(1):42-45. https://doi.org/10.25789/YMJ.2020.69.10
Views:
3
Email this article 