Results of study of parameters of biochemical and antioxidant status in patients with ovarian cancer during polychemotherapy
https://doi.org/10.25789/YMJ.2020.69.09
Abstract
A controlled open randomized study of the parameters of biochemical and antioxidant status in ovarian cancer patients was conducted. It was established that the administration of chemotherapeutic drugs contributes to a reliable increase of plasma levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lipid hydroperoxides, diene conjugates, malondialdehyde. Analysis of the influence of chemotherapy on the activity of antioxidant system components also showed a decrease in the content of ceruloplasmine and vitamin E. Thus, the inclusion of antioxidants in the treatment scheme of ovarian cancer patients should be considered pathogenetically justified, clinically reasonable and promising.
About the Authors
D. A. Bondarenko
Oncology Dispensary, Ministry of Health of the Khabarovsk Territory; Amur State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
BONDARENKO Dmitry Anatolyevich – Deputy Chief Medical Officer; Post-graduate student
681000, Komsomolskon-Amur, st. Ussuriyskaya, 5;
675006, Blagoveshchensk, st. Gorkogo, 95
D. V. Smirnov
Oncology Dispensary, Ministry of Health of the Khabarovsk Territory
Russian Federation
Russian Federation
SMIRNOV Dmitry Vladimirovich – Chief Medical Officer
681000, Komsomolsk-on-Amur, st. Ussuriyskaya, 5
N. V. Simonova
Amur State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
SIMONOVA Natalya Vladimirovna – doctor of biological sciences, professor
675006, Blagoveshchensk, st. Gorkogo, 95
V. A. Dorovskikh
Amur State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
DOROVSKIKH Vladimir Anatolyevich – doctor of medical sciences, professor
675006, Blagoveshchensk, st. Gorkogo, 95
R. A. Anokhina
Amur State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
ANOKHINA Raisa Afanasevna - candidate of medical sciences, associate professor
675006, Blagoveshchensk, st. Gorkogo, 95
M. A. Shtarberg
Amur State Medical Academy, Ministry of Health of Russia
Russian Federation
Russian Federation
SHTARBERG Mikhail Anatolyevich – candidate of medical sciences
675006, Blagoveshchensk, st. Gorkogo, 95
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Review
For citations:
Bondarenko D.A., Smirnov D.V., Simonova N.V., Dorovskikh V.A., Anokhina R.A., Shtarberg M.A. Results of study of parameters of biochemical and antioxidant status in patients with ovarian cancer during polychemotherapy. Yakut Medical Journal. 2020;(1):38-42. https://doi.org/10.25789/YMJ.2020.69.09
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