The comparative analysis of polymorphic variants of genes of predisposition to a multiple sclerosis in Slavs and Yakuts
Abstract
The purpose of research. The analysis of associations of polymorphic variants of interleukine genes IL1B, IL1RN, IL12B, TNFA, IL10 with risk of development of a multiple sclerosis at Russian and the Yakuts living in territory of Republic Sakha (Yakutia).
Materials and methods. 64 patients with the diagnosis a multiple sclerosis and the unrelated healthy persons selected on the basis of similarity to patients to attributes of age, sex and nationality (260 p. are surveyed.). Comparative analysis of polymorphism of interleukine genes (IL1B, IL1RN, IL12B, TNFa, IL10) is lead to two race - and ethnically differing groups of Yakuts and Russian inhabitants of Republic Sakha (Yakutia).
Results. In sample of Yakuts, in comparison with Russians, statistically significant prevalence of frequency of potentially pathological alleles is established: IL1B* (+3953Ф1) (0900 and 0,796 for Yakuts and Russian accordingly, р=0,001), IL12B* 1188С (0,331 and 0,191 accordingly, р <0,001), IL10* (-592С) (0,579 and 0,296 accordingly, р <0,001) and low frequency of the allele IL1RN* A2 (0,158 and 0,275 accordingly, р=0,002). Associations with a multiple sclerosis with one of the investigated polymorphic variants at Russian are not revealed. At the Yakuts with a multiple sclerosis, in comparison with the control, prevalence of frequency of the allele TNFa*А (0,357 and 0,133 accordingly, р=0,005) is shown.
About the Authors
I. A. Nikolaeva
ЯНЦ СО РАМН
Russian Federation
Russian Federation
S. A. Babenko
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
N. R. Maksimova
ЯНЦ СО РАМН
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Nikolaeva I.A., Babenko S.A., Maksimova N.R., Puzyrev V.P. The comparative analysis of polymorphic variants of genes of predisposition to a multiple sclerosis in Slavs and Yakuts. Yakut Medical Journal. 2007;(4):21-25. (In Russ.)
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