Studying of immunogenetic HLA marker in patients with hepatitis B in the Yakut population
Abstract
The purpose. Searching of immunogenetic HLA-a marker of a chronic virus hepatitis B (HVB).
Materials and methods. By means of molecular method HLA - genotyping in conformity with standards EFI (the European Federation of Immunogenetics) character of distribution of leucocytes antigens of class I and II loci A, B and DR among patients with a chronic hepatitis B in the Yakut population (n=64) is analyzed.
Results. In the Yakut population the statistical authentic association of a chronic virus hepatitis B with following antigens - HLAA23, A24, A26 and В18 and protective antigen HLA - B57 (p< 0,05) is established.
The conclusion. By results of research probably in the future by a multifactor method it would be possible to allocate the universal gene playing a role in transition of a hepatitis B in the chronic form. Searching of the immunogenetic markers HLA of a chronic virus hepatitis B, C and D in the Yakut population demands the further studying.
References
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Review
For citations:
Savin R.G. Studying of immunogenetic HLA marker in patients with hepatitis B in the Yakut population. Yakut Medical Journal. 2007;(3):31-33. (In Russ.)
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