Erythropoetin as a predictor of extremely severe course of new coronavirus infection COVID-19 in pregnant women
L. S. Ishchenko,
E. E. Voropaeva,
E. A. Kazachkova,
E. L. Kazachkov,
T. N. Shamaeva,
Y. S. Ishchenko https://doi.org/10.25789/YMJ.2024.86.14
Abstract
A comparative analysis of medical, social, clinical and laboratory parameters in pregnant women with a new coronavirus infection (NCI) COVID-19 of varying severity was carried out. For the first time, the level of serum erythropoietin was studied in this category of patients; for the first time, a statistically significantly lower level of erythropoietin was detected in pregnant women with extremely severe COVID-19. The threshold value of serum erythropoietin level was determined to predict the development of extremely severe COVID-19 in pregnant women.
About the Authors
L. S. Ishchenko
South Ural State Medical University MH RF; Regional Clinical Hospital No. 2
Russian Federation
Russian Federation
Ishchenko Lyudmila Stanislavovna – PhD in Medical Sciences, Associate Professor of the Department of obstetrics and gynecology of South Ural State Medical University of the Ministry of Health of the Russian Federation (MH RF), obstetrician-gynecologist Regional Clinical Hospital No. 2
E. E. Voropaeva
South Ural State Medical University MH RF; Regional Clinical Hospital No. 2
Russian Federation
Russian Federation
Voropaeva Ekaterina Evgenievna – MD, Professor, Professor of the Department of pathological anatomy and forensic medicine of South Ural State Medical University MH RF, Deputy Chief Physician for Obstetrics and Gynecology, Regional Clinical Hospital No. 2
E. A. Kazachkova
South Ural State Medical University MH RF
Russian Federation
Russian Federation
Kazachkova Ella Alekseevna – MD, Professor, Professor of the Department of Obstetrics and Gynecology
E. L. Kazachkov
Federal State Budgetary Educational Institution of the South Ural State Medical University MH RF
Russian Federation
Russian Federation
Kazachkov Evgeny Leonidovich – MD, Professor, Head of the Department of Pathological Anatomy and Forensic Medicine
T. N. Shamaeva
South Ural State Medical University MH RF
Russian Federation
Russian Federation
Shamaeva Tatiana Nikolaevna – PhD in Pedagogical Sciences, Associate Professor of the Department of Mathematics, Medical Informatics, Computer Science and Statistics, Physics of South Ural State Medical University MH RF
Y. S. Ishchenko
South Ural State Medical University MH RF
Russian Federation
Russian Federation
IShchenko Yulia Sergeevna – 4rd year student, Faculty of Pediatrics
References
1. Favorable outcome of the extremely severe course of the new coronavirus infection COVID-19 during pregnancy in the presence of overall lung damage, acute myocarditis, and myocardial infarction / E.E. Voropaeva [et al.] // Obstetrics and Gynecology. 2021. №10. P. 179-186. DOI: 10.18565/aig.2021.10.179-186.
2. Temporary methodological recommendations. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 18 (26.10.2023) [Internet]. URL: https://static0.minzdrav.gov.ru/system/attachments/attaches/000/064/610/original/ВМР_COVID-19_V18.pdf
3. Zakharov Yu.М. Non-erythropoietic properties of erythropoietin // Russian Journal of Physiology. 2007. Vol.93, №6. P. 592-608.
4. Final statement on the work of the fifteenth meeting of the International Health Regulations Committee (2005) on the pandemic emergency [Internet]. URL: https://www.who.int/ru/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic5.
5. Lykov A.P. Erythropoietin: function and therapeutic potential // Siberian scientific medical journal. 2023. Vol.43, №3. P. 29-39. DOI: 10.18699/sSMJ20230203.
6. Morphofunctional characteristics of erythrocytes and blood erythropoietin level in patients as predictors of severe course of COVID-19 / V.V. Revin [et al.] // Bulletin of Experimental Biology and Medicine. 2022. Vol.173, №1. P. 57-61. DOI: 10.47056/0365-9615-2022-173-1-57-61.
7. Experience in managing severe and extremely severe COVID-19 in pregnant women / A.I. Gareyeva [et al.] // Journal of Obstetrics and Women's Diseases. 2022. Vol.71, №1. P. 11-22. DOI: 10.17816/JOWD72169.
8. Peculiarities of hemostasis in pregnant women during manifestation of new coronavirus infection COVID-19 in the third trimester of gestation / L.S. Ishchenko [et al.] //south Ural medical journal. 2021. №3. P. 60-74.
9. Rehabilitation during the COVID-19 pandemic / A.S. Golota [et al.] // Clinical Practice. 2022. Vol.13, №1. P. 42-65. DOI: 10.17816/clinpract79364.
10. COVID-19 in pregnant women of Siberia and the Russian Far East: 2-year results of the pandemic / T.E. Belokrinitskaya [et al.] // Obstetrics and Gynecology. 2022. №4. С. 47-54. DOI: 10.18565/aig.2022.4.47-54.
11. Frequency and outcomes of extremely early preterm birth in pregnant women with new coronavirus infection COVID-19 / L.S. Ishchenko [et al.] // Yakut Medical Journal. 2023. №1. P. 80-83. DOI: 10.25789/YMJ.2023.81.20.
12. Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells / B.B. Beleslin-Čokić [et al.] // Cytokine. 2011; 54(2): 129-35. DOI: 10.1016/j.cyto.2011.01.015.
13. Broxmeyer H.E. Erythropoietin surprises: an immune saga // Immunity. 2011; 34(1): 6-7. DOI: 10.1016/j.immuni.2011.01.004.
14. Erythropoietin protects against diabetes through direct effects on pancreatic beta cells / D. Choi [et al.] // J Exp Med. 2010; 207(13): 28312842. DOI: 10.1084/jem.20100665.
15. Clinical characteristics andoutcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis / M. Jafari [et al.] // Rev Med Virol. 2021; 31(5): 1-16. DOI: 10.1002/rmv.2208.
16. Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis / B. Gungor [et al.] // Am J Emerg Med. 2021; 39: 173-179. DOI:10.1016/j.ajem.2020.09.018.
17. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis / D. Liu [et al.] // AJR Am J Roentgenol. 2020; 215(1): 127-132. DOI: 10.2214/AJR.20.23072.
18. Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS-CoV-2 infection among hospitalized pregnant women: A systematic review / O. Turan [et al.] // Int J Gynecol Obstet. 2020; 151(1): 7-16. DOI: 10.1002/ijgo.13329ijgo.13329.
19. Vallejo V., Ilagan J.G. A Postpartum Death Due to Coronavirus Disease 2019 (COVID-19) in the United States // Obstet Gynecol. 2020; 136(1): 52-55. DOI: 10.1097/AOG.0000000000003950.
20. Low serum erythropoietin levels are associated with fatal COVID-19 cases at 4,150 meters above sea level / A. Viruez-Soto [et al.] // Respir Physiol Neurobiol. 2021; 292(103709): 1-5. DOI: 10.1016/j.resp.2021.103709.
21. The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID-19 /s. Yağcı [et al.] // Int J Lab Hematol. 2021; 43 (Suppl 1): 142-151. DOI: 10.1111/ijlh.13479.
Review
For citations:
Ishchenko L.S., Voropaeva E.E., Kazachkova E.A., Kazachkov E.L., Shamaeva T.N., Ishchenko Y.S. Erythropoetin as a predictor of extremely severe course of new coronavirus infection COVID-19 in pregnant women. Yakut Medical Journal. 2024;(2):59-63. https://doi.org/10.25789/YMJ.2024.86.14
Views:
33
Email this article 